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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Pharmacology Research Group > Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/7692
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Title: Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Authors: Schuh, Kai
Cartwright, Elizabeth J.
Jankevics, Eriks
Bundschu, Karin
Liebermann, Jürgen
Williams, Judith C.
Armesilla, Angel Luis
Emerson, Michael
Oceandy, Delvac
Knobeloch, Klaus-Peter
Neyses, Ludwig
Citation: The Journal of Biological Chemistry, 279(27): 28220-28226
Publisher: American Society for Biochemistry and Molecular Biology
Issue Date: 2004
URI: http://hdl.handle.net/2436/7692
DOI: 10.1074/jbc.M312599200
PubMed ID: 15078889
Additional Links: http://www.jbc.org/cgi/content/abstract/279/27/28220
http://direct.bl.uk/bld/PlaceOrder.do?UIN=152341633&ETOC=RN&from=searchengine
Abstract: Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels.
Type: Article
Language: en
Keywords: Plasma Membrane
Sperm Motility
Male Fertility
Ca2+
ISSN: 0021-9258
Appears in Collections: Molecular Pharmacology Research Group

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