2.50
Hdl Handle:
http://hdl.handle.net/2436/7691
Title:
Heterogeneity of viral IL-6 expression in HHV-8-associated diseases.
Authors:
Cannon, Jennifer S.; Nicholas, John; Orenstein, Jan M.; Mann, Risa B.; Murray, Paul G.; Browning, Philip J.; DiGiuseppe, Joseph A.; Cesarman, Ethel; Hayward, Gary S.; Ambinder, Richard F.
Abstract:
In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.
Citation:
Journal of Infectious Diseases, 180(3): 824-828
Publisher:
University of Chicago Press
Issue Date:
1999
URI:
http://hdl.handle.net/2436/7691
DOI:
10.1086/314956
PubMed ID:
10438372
Additional Links:
http://www.journals.uchicago.edu/doi/abs/10.1086/314956; http://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchengine
Submitted date:
2007-01-19
Type:
Article
Language:
en
ISSN:
0022-1899
Appears in Collections:
Centre for Health and Social Care Improvement

Full metadata record

DC FieldValue Language
dc.contributor.authorCannon, Jennifer S.-
dc.contributor.authorNicholas, John-
dc.contributor.authorOrenstein, Jan M.-
dc.contributor.authorMann, Risa B.-
dc.contributor.authorMurray, Paul G.-
dc.contributor.authorBrowning, Philip J.-
dc.contributor.authorDiGiuseppe, Joseph A.-
dc.contributor.authorCesarman, Ethel-
dc.contributor.authorHayward, Gary S.-
dc.contributor.authorAmbinder, Richard F.-
dc.date.accessioned2007-01-23T14:55:02Z-
dc.date.available2007-01-23T14:55:02Z-
dc.date.issued1999-
dc.date.submitted2007-01-19-
dc.identifier.citationJournal of Infectious Diseases, 180(3): 824-828en
dc.identifier.issn0022-1899-
dc.identifier.pmid10438372-
dc.identifier.doi10.1086/314956-
dc.identifier.urihttp://hdl.handle.net/2436/7691-
dc.description.abstractIn order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.en
dc.format.extent900404 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.publisherUniversity of Chicago Pressen
dc.relation.urlhttp://www.journals.uchicago.edu/doi/abs/10.1086/314956en
dc.relation.urlhttp://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchengine-
dc.subjectViral interleukin-6 (vIL-6) homologueen
dc.subjectHuman herpesvirus 8en
dc.subjectHHV-8en
dc.titleHeterogeneity of viral IL-6 expression in HHV-8-associated diseases.en
dc.typeArticleen
dc.format.digYES-

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