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Wolverhampton Intellectual Repository and E-Theses > School of Health & Wellbeing > Centre for Health and Social Care Improvement > Heterogeneity of viral IL-6 expression in HHV-8-associated diseases.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/7691
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Title: Heterogeneity of viral IL-6 expression in HHV-8-associated diseases.
Authors: Cannon, Jennifer S.
Nicholas, John
Orenstein, Jan M.
Mann, Risa B.
Murray, Paul G.
Browning, Philip J.
DiGiuseppe, Joseph A.
Cesarman, Ethel
Hayward, Gary S.
Ambinder, Richard F.
Citation: Journal of Infectious Diseases, 180(3): 824-828
Publisher: University of Chicago Press
Issue Date: 1999
URI: http://hdl.handle.net/2436/7691
DOI: 10.1086/314956
PubMed ID: 10438372
Additional Links: http://www.journals.uchicago.edu/doi/abs/10.1086/314956
http://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchengine
Abstract: In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.
Type: Article
Language: en
Keywords: Viral interleukin-6 (vIL-6) homologue
Human herpesvirus 8
HHV-8
ISSN: 0022-1899
Appears in Collections: Centre for Health and Social Care Improvement

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