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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Bovine enterovirus as an oncolytic virus: foetal calf serum facilitates its infection of human cells.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/7688
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Title: Bovine enterovirus as an oncolytic virus: foetal calf serum facilitates its infection of human cells.
Authors: Smyth, M.S.
Symonds, A.
Brazinova, S.
Martin, Jan H.
Citation: International Journal of Molecular Medicine, 10(1): 49-53
Publisher: University of Crete
Issue Date: 2002
URI: http://hdl.handle.net/2436/7688
PubMed ID: 12060850
Additional Links: http://www.ncbi.nlm.nih.gov/pubmed/12060850
http://direct.bl.uk/bld/PlaceOrder.do?UIN=114726394&ETOC=RN&from=searchengine
Abstract: Many viruses have been investigated for their oncolytic properties and potential use as therapeutic agents for cancer treatment. Most of these replication-competent viruses are human pathogens. We investigated the oncolytic properties of an animal virus which is non pathogenic for both its natural host and humans. Bovine enterovirus has previously been shown to exhibit a very wide tissue tropism for cell types in vitro. We compare the ability of bovine enterovirus to replicate in and to cause cytopathic effect in freshly isolated human monocytes and monocyte derived macrophages with the monocyte-like U937 tumour cell line. We also include the adherent ZR-75-1 human breast cancer cell line. We have also carried out infections of bovine enterovirus in the presence and in the absence of serum of bovine origin. Our study shows that the virus will replicate in and produce cytopathic effect in the U937 and ZR-75-1 cell types to the same extent as the cells (BHK-21) in which the virus is routinely propagated. We believe bovine enterovirus to be a worthwhile candidate for further study as an anti-tumour agent.
Type: Article
Language: en
Keywords: Oncology
Animal viruses
Cancer treatment
Bovine enteroviruses
ISSN: 1107-3756
Appears in Collections: Cancer Research Group

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