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Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.
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| Title: | Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. |
| Authors: | Panoulas, Vasileios F.
Douglas, Karen M. J.
Smith, Jacqueline P.
Metsios, Giorgos S.
Elisaf, Moses S.
Nightingale, Peter
Kitas, George D. |
| Citation: | Clinical and Experimental Hypertension, 31(2): 93-104 |
| Publisher: | Informaworld (Taylor & Francis) |
| Journal: | Clinical and Experimental Hypertension |
| Issue Date: | 2009 |
| URI: | http://hdl.handle.net/2436/66833 |
| DOI: | 10.1080/10641960802621267 |
| PubMed ID: | 19330599 |
| Additional Links: | http://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562 |
| Abstract: | The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations. |
| Type: | Article |
| Language: | en |
| Keywords: | Arthritis, Rheumatoid
Prevalence
Rheumatoid Arthritis
Cardiovascular Disease
Blood Pressure
Hypertension
Galectin-2
LGALS2
rs7291467
Polymorphism
Genetics |
| ISSN: | 1525-6006
0148-3927 |
| Appears in Collections: | Sport, Exercise and Health Research Group
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