Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.

2.50
Hdl Handle:
http://hdl.handle.net/2436/66833
Title:
Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.
Authors:
Panoulas, Vasileios F.; Douglas, Karen M. J.; Smith, Jacqueline P.; Metsios, Giorgos S.; Elisaf, Moses S.; Nightingale, Peter; Kitas, George D.
Abstract:
The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
Citation:
Clinical and Experimental Hypertension, 31(2): 93-104
Publisher:
Informaworld (Taylor & Francis)
Journal:
Clinical and Experimental Hypertension
Issue Date:
2009
URI:
http://hdl.handle.net/2436/66833
DOI:
10.1080/10641960802621267
PubMed ID:
19330599
Additional Links:
http://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562
Type:
Article
Language:
en
ISSN:
1525-6006; 0148-3927
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorPanoulas, Vasileios F.-
dc.contributor.authorDouglas, Karen M. J.-
dc.contributor.authorSmith, Jacqueline P.-
dc.contributor.authorMetsios, Giorgos S.-
dc.contributor.authorElisaf, Moses S.-
dc.contributor.authorNightingale, Peter-
dc.contributor.authorKitas, George D.-
dc.date.accessioned2009-04-30T19:44:39Z-
dc.date.available2009-04-30T19:44:39Z-
dc.date.issued2009-
dc.identifier.citationClinical and Experimental Hypertension, 31(2): 93-104en
dc.identifier.issn1525-6006-
dc.identifier.issn0148-3927-
dc.identifier.pmid19330599-
dc.identifier.doi10.1080/10641960802621267-
dc.identifier.urihttp://hdl.handle.net/2436/66833-
dc.description.abstractThe galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.en
dc.language.isoenen
dc.publisherInformaworld (Taylor & Francis)en
dc.relation.urlhttp://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562en
dc.subjectArthritis, Rheumatoiden
dc.subjectPrevalence-
dc.subjectRheumatoid Arthritis-
dc.subjectCardiovascular Disease-
dc.subjectBlood Pressure-
dc.subjectHypertension-
dc.subjectGalectin-2-
dc.subjectLGALS2-
dc.subjectrs7291467-
dc.subjectPolymorphism-
dc.subjectGenetics-
dc.titleGalectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.en
dc.typeArticleen
dc.identifier.journalClinical and Experimental Hypertensionen

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