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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/66833
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Title: Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.
Authors: Panoulas, Vasileios F.
Douglas, Karen M. J.
Smith, Jacqueline P.
Metsios, Giorgos S.
Elisaf, Moses S.
Nightingale, Peter
Kitas, George D.
Citation: Clinical and Experimental Hypertension, 31(2): 93-104
Publisher: Informaworld (Taylor & Francis)
Journal: Clinical and Experimental Hypertension
Issue Date: 2009
URI: http://hdl.handle.net/2436/66833
DOI: 10.1080/10641960802621267
PubMed ID: 19330599
Additional Links: http://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562
Abstract: The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
Type: Article
Language: en
Keywords: Arthritis, Rheumatoid
Prevalence
Rheumatoid Arthritis
Cardiovascular Disease
Blood Pressure
Hypertension
Galectin-2
LGALS2
rs7291467
Polymorphism
Genetics
ISSN: 1525-6006
0148-3927
Appears in Collections: Sport, Exercise and Health Research Group

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