Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

2.50
Hdl Handle:
http://hdl.handle.net/2436/621099
Title:
Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis
Authors:
Fenton, Sally A. M.; Metsios, Giorgos S.; Duda, Joan L.; Kitas, George D.; van Zanten, JV
Abstract:
Background: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. Objectives: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. Methods: Sixty-eight RA patients (Mage = 55±12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). Results: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = − 3.25, p = .02, 95% CI [– 6.07, – .42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). Conclusion: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.
Publisher:
Elsevier
Journal:
Microvascular Research
Issue Date:
May-2018
URI:
http://hdl.handle.net/2436/621099
Additional Links:
https://www.sciencedirect.com/journal/microvascular-research
Type:
Article
Language:
en
ISSN:
0026-2862
Appears in Collections:
FEHW

Full metadata record

DC FieldValue Language
dc.contributor.authorFenton, Sally A. M.en
dc.contributor.authorMetsios, Giorgos S.en
dc.contributor.authorDuda, Joan L.en
dc.contributor.authorKitas, George D.en
dc.contributor.authorvan Zanten, JVen
dc.date.accessioned2018-02-12T12:38:24Z-
dc.date.available2018-02-12T12:38:24Z-
dc.date.issued2018-05-
dc.identifier.issn0026-2862en
dc.identifier.urihttp://hdl.handle.net/2436/621099-
dc.description.abstractBackground: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. Objectives: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. Methods: Sixty-eight RA patients (Mage = 55±12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). Results: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = − 3.25, p = .02, 95% CI [– 6.07, – .42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). Conclusion: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/journal/microvascular-researchen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCardiovascular diseaseen
dc.subjectEndothelial functionen
dc.subjectRheumatoid arthritisen
dc.subjectSedentary behaviouren
dc.subjectUltrasonographyen
dc.titleSitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritisen
dc.typeArticleen
dc.identifier.journalMicrovascular Researchen
dc.date.accepted2018-01-
rioxxterms.funderMRCen
rioxxterms.identifier.project120218GSMen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-05-01en
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