Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations

2.50
Hdl Handle:
http://hdl.handle.net/2436/621029
Title:
Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations
Authors:
Molina, Carlos; Kaialy, Waseem; Chen, Qiao; Commandeur, Daniel; Nokhodchi, Ali ( 0000-0002-3244-2482 )
Abstract:
Spray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactoseleucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle size), differential scanning calorimetry (thermal behavior), scanning electron microscopy (morphology), powder X-ray diffraction (crystallinity), Fourier transform infrared spectroscopy (interaction at molecular level), and in vitro aerosolization performance (deposition). The results showed that the efficacy of salbutamol sulfate’s aerosolization performance was, in part, due to the introduction of L-leucine in the carrier, prior to being spray-dried, accounting for an increase in the fine particle fraction (FPF) of salbutamol sulfate from spray-dried lactose-leucine (0.5% leucine) in comparison to all other carriers. It was shown that all of the spray-dried carriers were spherical in their morphology with some agglomerates and contained a mixture of amorphous, α- lactose, and β-lactose. It was also interesting to note that spray-dried lactose-leucine particles were agglomerated during the spray-drying process to make coarse particles (volume mean diameter of 79 to 87 μm) suitable as a carrier in DPI formulations.
Citation:
Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations 2017 Drug Delivery and Translational Research
Publisher:
Springer
Journal:
Drug Delivery and Translational Research
Issue Date:
19-Dec-2017
URI:
http://hdl.handle.net/2436/621029
DOI:
10.1007/s13346-017-0462-8
Additional Links:
http://link.springer.com/10.1007/s13346-017-0462-8
Type:
Article
Language:
en
ISSN:
2190-393X
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorMolina, Carlosen
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorChen, Qiaoen
dc.contributor.authorCommandeur, Danielen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2018-01-09T09:25:56Z-
dc.date.available2018-01-09T09:25:56Z-
dc.date.issued2017-12-19-
dc.identifier.citationAgglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations 2017 Drug Delivery and Translational Researchen
dc.identifier.issn2190-393Xen
dc.identifier.doi10.1007/s13346-017-0462-8-
dc.identifier.urihttp://hdl.handle.net/2436/621029-
dc.description.abstractSpray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactoseleucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle size), differential scanning calorimetry (thermal behavior), scanning electron microscopy (morphology), powder X-ray diffraction (crystallinity), Fourier transform infrared spectroscopy (interaction at molecular level), and in vitro aerosolization performance (deposition). The results showed that the efficacy of salbutamol sulfate’s aerosolization performance was, in part, due to the introduction of L-leucine in the carrier, prior to being spray-dried, accounting for an increase in the fine particle fraction (FPF) of salbutamol sulfate from spray-dried lactose-leucine (0.5% leucine) in comparison to all other carriers. It was shown that all of the spray-dried carriers were spherical in their morphology with some agglomerates and contained a mixture of amorphous, α- lactose, and β-lactose. It was also interesting to note that spray-dried lactose-leucine particles were agglomerated during the spray-drying process to make coarse particles (volume mean diameter of 79 to 87 μm) suitable as a carrier in DPI formulations.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://link.springer.com/10.1007/s13346-017-0462-8en
dc.rightsArchived with thanks to Drug Delivery and Translational Researchen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDry powder inhaleren
dc.subjectSpray-dryingen
dc.subjectAgglomerationen
dc.subjectSalbutamol sulfateen
dc.subjectLeucineen
dc.titleAgglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulationsen
dc.typeArticleen
dc.identifier.journalDrug Delivery and Translational Researchen
dc.date.accepted2017-12-
rioxxterms.funderInternalen
rioxxterms.identifier.project090118WKen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-12-18en
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