Biological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicity

2.50
Hdl Handle:
http://hdl.handle.net/2436/621022
Title:
Biological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicity
Authors:
Krucińska, Izabella; Żywicka, Bogusława; Komisarczyk, Agnieszka; Szymonowicz, Maria; Kowalska, Stanisława; Zaczyńska, Ewa; Struszczyk, Marcin; Czarny, Anna; Jadczyk, Piotr; Umińska-Wasiluk, Barbara; Rybak, Zbigniew; Kowalczuk, Marek ( 0000-0002-2877-7466 )
Abstract:
In response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(L-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and L-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)4 as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation. The bioactivity of the proposed implants has been imparted by introducing a hydroxyapatite material and IGF1, a growth factor. The developed prototypes of implants have been subjected to a set of in vitro and in vivobiocompatibility tests: in vitro cytotoxic effect, in vitro genotoxicity and systemic toxicity. Rabbitsshowed no signs of negative reactionafter implantation of the experimental implant prototypes.
Citation:
Biological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicity 2017, 22 (12):2092 Molecules
Publisher:
MDPI
Journal:
Molecules
Issue Date:
29-Nov-2017
URI:
http://hdl.handle.net/2436/621022
DOI:
10.3390/molecules22122092
Additional Links:
http://www.mdpi.com/1420-3049/22/12/2092
Type:
Article
Language:
en
ISSN:
1420-3049
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKrucińska, Izabellaen
dc.contributor.authorŻywicka, Bogusławaen
dc.contributor.authorKomisarczyk, Agnieszkaen
dc.contributor.authorSzymonowicz, Mariaen
dc.contributor.authorKowalska, Stanisławaen
dc.contributor.authorZaczyńska, Ewaen
dc.contributor.authorStruszczyk, Marcinen
dc.contributor.authorCzarny, Annaen
dc.contributor.authorJadczyk, Piotren
dc.contributor.authorUmińska-Wasiluk, Barbaraen
dc.contributor.authorRybak, Zbigniewen
dc.contributor.authorKowalczuk, Mareken
dc.date.accessioned2018-01-08T09:53:30Z-
dc.date.available2018-01-08T09:53:30Z-
dc.date.issued2017-11-29-
dc.identifier.citationBiological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicity 2017, 22 (12):2092 Moleculesen
dc.identifier.issn1420-3049en
dc.identifier.doi10.3390/molecules22122092-
dc.identifier.urihttp://hdl.handle.net/2436/621022-
dc.description.abstractIn response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(L-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and L-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)4 as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation. The bioactivity of the proposed implants has been imparted by introducing a hydroxyapatite material and IGF1, a growth factor. The developed prototypes of implants have been subjected to a set of in vitro and in vivobiocompatibility tests: in vitro cytotoxic effect, in vitro genotoxicity and systemic toxicity. Rabbitsshowed no signs of negative reactionafter implantation of the experimental implant prototypes.en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttp://www.mdpi.com/1420-3049/22/12/2092en
dc.rightsArchived with thanks to Moleculesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbiotoxicityen
dc.subjectbiodegradationen
dc.subjectcytotoxicityen
dc.subjectgenotoxicityen
dc.subjecthemocompatabilityen
dc.subjectnonwoven fabricsen
dc.subjectbone implanten
dc.subjectpoly(L-lactide-co-glycolide)en
dc.subjectsynthetic poly([R,S]-3-hydroxybutyrate)en
dc.subjectencapsulated growth factoren
dc.titleBiological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicityen
dc.typeArticleen
dc.identifier.journalMoleculesen
dc.date.accepted2017-10-
rioxxterms.funderEuropean Regional Development Fund, National Science Centre (NCN) Poland, Central Europe Programme, University of Wolverhamptonen
rioxxterms.identifier.projectStructural Founds in the frame of “Biodegradable fibrous products” project (acronym BIOGRATEX) no. POIG01.03.01-00-07/08-09)en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-01-08en
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