The cytotoxic mechanisms of disulfiram and copper( ii ) in cancer cells

2.50
Hdl Handle:
http://hdl.handle.net/2436/620945
Title:
The cytotoxic mechanisms of disulfiram and copper( ii ) in cancer cells
Authors:
Tawari, Patricia Erebi; Wang, Zhipeng; Najlah, Mohammad; Tsang, Chi Wai; Kannappan, Vinodh; Liu, Peng; McConville, Christopher; He, Bin; Armesilla, Angel L.; Wang, Weiguang
Abstract:
The anticancer activity of disulfiram (DS) is copper(II) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment
Citation:
The cytotoxic mechanisms of disulfiram and copper( ii ) in cancer cells 2015, 4 (6):1439 Toxicology Research
Publisher:
Royal Society of Chemistry
Journal:
Toxicology Research
Issue Date:
2015
URI:
http://hdl.handle.net/2436/620945
DOI:
10.1039/C5TX00210A
Additional Links:
http://xlink.rsc.org/?DOI=C5TX00210A
Type:
Article
Language:
en
ISSN:
2045-452X; 2045-4538
Sponsors:
EU Commission
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorTawari, Patricia Erebien
dc.contributor.authorWang, Zhipengen
dc.contributor.authorNajlah, Mohammaden
dc.contributor.authorTsang, Chi Waien
dc.contributor.authorKannappan, Vinodhen
dc.contributor.authorLiu, Pengen
dc.contributor.authorMcConville, Christopheren
dc.contributor.authorHe, Binen
dc.contributor.authorArmesilla, Angel L.en
dc.contributor.authorWang, Weiguangen
dc.date.accessioned2017-12-04T16:39:36Z-
dc.date.available2017-12-04T16:39:36Z-
dc.date.issued2015-
dc.identifier.citationThe cytotoxic mechanisms of disulfiram and copper( ii ) in cancer cells 2015, 4 (6):1439 Toxicology Researchen
dc.identifier.issn2045-452X-
dc.identifier.issn2045-4538-
dc.identifier.doi10.1039/C5TX00210A-
dc.identifier.urihttp://hdl.handle.net/2436/620945-
dc.description.abstractThe anticancer activity of disulfiram (DS) is copper(II) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatmenten
dc.description.sponsorshipEU Commissionen
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.urlhttp://xlink.rsc.org/?DOI=C5TX00210Aen
dc.rightsArchived with thanks to Toxicology Researchen
dc.subjectDisulfiramen
dc.subjectROSen
dc.subjectCopperen
dc.titleThe cytotoxic mechanisms of disulfiram and copper( ii ) in cancer cellsen
dc.typeArticleen
dc.identifier.journalToxicology Researchen
dc.contributor.institutionResearch Institute in Healthcare Science-
dc.contributor.institutionResearch Institute in Healthcare Science-
dc.contributor.institutionMedicine & Healthcare Science-
dc.contributor.institutionSchool of Chemistry-
dc.contributor.institutionResearch Institute in Healthcare Science-
dc.contributor.institutionResearch Institute in Healthcare Science-
dc.contributor.institutionSchool of Pharmacy-
dc.contributor.institutionNational Engineering Res Centre for Biomaterials-
dc.contributor.institutionResearch Institute in Healthcare Science-
dc.contributor.institutionResearch Institute in Healthcare Science-
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