2.50
Hdl Handle:
http://hdl.handle.net/2436/620934
Title:
Strategies for antimicrobial drug delivery to biofilm.
Authors:
Martin, Claire; Low, Wan Li; Gupta, Abhishek; Amin, Mohd Cairul Iqbal Mohd; Radecka, Iza; Britland, Stephen T; Raj, Prem; Kenward, Ken M A
Abstract:
Biofilms are formed by the attachment of single or mixed microbial communities to a variety of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many advantages of the polymicrobial environment including increased resistance against antimicrobials and protection against the host organism's defence mechanisms. These benefits stem from a number of structural and physiological differences between planktonic and biofilm-resident microbes, but two main factors are the presence of extracellular polymeric substances (EPS) and quorum sensing communication. Once formed, biofilms begin to synthesise EPS, a complex viscous matrix composed of a variety of macromolecules including proteins, lipids and polysaccharides. In terms of drug delivery strategies, it is the EPS that presents the greatest barrier to diffusion for drug delivery systems and free antimicrobial agents alike. In addition to EPS synthesis, biofilm-based micro-organisms can also produce small, diffusible signalling molecules involved in cell density-dependent intercellular communication, or quorum sensing. Not only does quorum sensing allow microbes to detect critical cell density numbers, but it also permits co-ordinated behaviour within the biofilm, such as iron chelation and defensive antibiotic activities. Against this backdrop of microbial defence and cell density-specific communication, a variety of drug delivery systems have been developed to deliver antimicrobial agents and antibiotics to extracellular and/or intracellular targets, or more recently, to interfere with the specific mechanisms of quorum sensing. Successful delivery strategies have employed lipidic and polymeric-based formulations such as liposomes and cyclodextrins respectively, in addition to inorganic carriers e.g. metal nanoparticles. This review will examine a range of drug delivery systems and their application to biofilm delivery, as well as pharmaceutical formulations with innate antimicrobial properties such as silver nanoparticles and microemulsions.
Citation:
Strategies for antimicrobial drug delivery to biofilm. 2015, 21 (1):43-66 Curr. Pharm. Des.
Journal:
Current pharmaceutical design
Issue Date:
2015
URI:
http://hdl.handle.net/2436/620934
PubMed ID:
25189862
Type:
Article
Language:
en
ISSN:
1873-4286
Sponsors:
University of Wolverhampton, UK ; Universiti Kebangsaan Malaysia, Malaysia.
Appears in Collections:
Applied Microbiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Claireen
dc.contributor.authorLow, Wan Lien
dc.contributor.authorGupta, Abhisheken
dc.contributor.authorAmin, Mohd Cairul Iqbal Mohden
dc.contributor.authorRadecka, Izaen
dc.contributor.authorBritland, Stephen Ten
dc.contributor.authorRaj, Premen
dc.contributor.authorKenward, Ken M Aen
dc.date.accessioned2017-11-30T11:50:02Z-
dc.date.available2017-11-30T11:50:02Z-
dc.date.issued2015-
dc.identifier.citationStrategies for antimicrobial drug delivery to biofilm. 2015, 21 (1):43-66 Curr. Pharm. Des.en
dc.identifier.issn1873-4286-
dc.identifier.pmid25189862-
dc.identifier.urihttp://hdl.handle.net/2436/620934-
dc.description.abstractBiofilms are formed by the attachment of single or mixed microbial communities to a variety of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many advantages of the polymicrobial environment including increased resistance against antimicrobials and protection against the host organism's defence mechanisms. These benefits stem from a number of structural and physiological differences between planktonic and biofilm-resident microbes, but two main factors are the presence of extracellular polymeric substances (EPS) and quorum sensing communication. Once formed, biofilms begin to synthesise EPS, a complex viscous matrix composed of a variety of macromolecules including proteins, lipids and polysaccharides. In terms of drug delivery strategies, it is the EPS that presents the greatest barrier to diffusion for drug delivery systems and free antimicrobial agents alike. In addition to EPS synthesis, biofilm-based micro-organisms can also produce small, diffusible signalling molecules involved in cell density-dependent intercellular communication, or quorum sensing. Not only does quorum sensing allow microbes to detect critical cell density numbers, but it also permits co-ordinated behaviour within the biofilm, such as iron chelation and defensive antibiotic activities. Against this backdrop of microbial defence and cell density-specific communication, a variety of drug delivery systems have been developed to deliver antimicrobial agents and antibiotics to extracellular and/or intracellular targets, or more recently, to interfere with the specific mechanisms of quorum sensing. Successful delivery strategies have employed lipidic and polymeric-based formulations such as liposomes and cyclodextrins respectively, in addition to inorganic carriers e.g. metal nanoparticles. This review will examine a range of drug delivery systems and their application to biofilm delivery, as well as pharmaceutical formulations with innate antimicrobial properties such as silver nanoparticles and microemulsions.en
dc.description.sponsorshipUniversity of Wolverhampton, UK ; Universiti Kebangsaan Malaysia, Malaysia.en
dc.language.isoenen
dc.rightsArchived with thanks to Current pharmaceutical designen
dc.subjectBiofilmen
dc.subjectantimicrobial agentsen
dc.subjectcontrolled releaseen
dc.subjectdrug delivery systemsen
dc.subjectliposomesen
dc.subjectsolid lipid nanoparticlesen
dc.subjectmicroemulsionsen
dc.subjectmicro- and nanoparticlesen
dc.subjectsmart polymersen
dc.subjectdendrimersen
dc.subjectcyclodextrinsen
dc.subjectsilveren
dc.subjectgolden
dc.subjectcopperen
dc.subjectzincen
dc.subjectiron saltsen
dc.subject.meshAnimals-
dc.subject.meshAnti-Infective Agents-
dc.subject.meshBiofilms-
dc.subject.meshCell Communication-
dc.subject.meshCell Count-
dc.subject.meshDrug Delivery Systems-
dc.subject.meshDrug Resistance, Microbial-
dc.subject.meshEmulsions-
dc.subject.meshHumans-
dc.subject.meshMetal Nanoparticles-
dc.subject.meshQuorum Sensing-
dc.titleStrategies for antimicrobial drug delivery to biofilm.en
dc.typeArticleen
dc.identifier.journalCurrent pharmaceutical designen

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