Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children.

2.50
Hdl Handle:
http://hdl.handle.net/2436/620759
Title:
Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children.
Authors:
Deli, Chariklia K; Fatouros, Ioannis G; Paschalis, Vassilis; Tsiokanos, Athanasios; Georgakouli, Kalliopi; Zalavras, Athanasios; Avloniti, Alexandra; Koutedakis, Yiannis; Jamurtas, Athanasios Z
Abstract:
Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619.
Citation:
Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. 2017, 2017:4120421 Oxid Med Cell Longev
Publisher:
Hindawi Publishing Corporation
Journal:
Oxidative medicine and cellular longevity
Issue Date:
2017
URI:
http://hdl.handle.net/2436/620759
DOI:
10.1155/2017/4120421
PubMed ID:
28203319
Type:
Book
Language:
en
ISSN:
1942-0900
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorDeli, Chariklia Ken
dc.contributor.authorFatouros, Ioannis Gen
dc.contributor.authorPaschalis, Vassilisen
dc.contributor.authorTsiokanos, Athanasiosen
dc.contributor.authorGeorgakouli, Kalliopien
dc.contributor.authorZalavras, Athanasiosen
dc.contributor.authorAvloniti, Alexandraen
dc.contributor.authorKoutedakis, Yiannisen
dc.contributor.authorJamurtas, Athanasios Zen
dc.date.accessioned2017-10-12T13:02:06Z-
dc.date.available2017-10-12T13:02:06Z-
dc.date.issued2017-
dc.identifier.citationIron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. 2017, 2017:4120421 Oxid Med Cell Longeven
dc.identifier.issn1942-0900en
dc.identifier.pmid28203319-
dc.identifier.doi10.1155/2017/4120421-
dc.identifier.urihttp://hdl.handle.net/2436/620759-
dc.description.abstractExercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.rightsArchived with thanks to Oxidative medicine and cellular longevityen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshChild-
dc.subject.meshCross-Over Studies-
dc.subject.meshDietary Supplements-
dc.subject.meshDouble-Blind Method-
dc.subject.meshExercise-
dc.subject.meshHumans-
dc.subject.meshIron-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscle, Skeletal-
dc.subject.meshOxidation-Reduction-
dc.subject.meshOxidative Stress-
dc.subject.meshReactive Nitrogen Species-
dc.subject.meshReactive Oxygen Species-
dc.subject.meshYoung Adult-
dc.titleIron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children.en
dc.typeBooken
dc.identifier.journalOxidative medicine and cellular longevityen
dc.date.accepted2016-11-24-
rioxxterms.funderinternalen
rioxxterms.identifier.projectUOW121017YKen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-10-12en

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