Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children
Authors
Deli, Chariklia KFatouros, Ioannis G
Paschalis, Vassilis
Tsiokanos, Athanasios
Georgakouli, Kalliopi
Zalavras, Athanasios
Avloniti, Alexandra
Koutedakis, Yiannis
Jamurtas, Athanasios Z
Issue Date
2017
Metadata
Show full item recordAbstract
Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619.Citation
Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. 2017, 2017:4120421 Oxid Med Cell LongevPublisher
HindawiJournal
Oxidative medicine and cellular longevityPubMed ID
28203319Type
Journal articleLanguage
enISSN
1942-0900ae974a485f413a2113503eed53cd6c53
10.1155/2017/4120421
Scopus Count
Collections
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
Related articles
- No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training.
- Authors: Theodorou AA, Nikolaidis MG, Paschalis V, Koutsias S, Panayiotou G, Fatouros IG, Koutedakis Y, Jamurtas AZ
- Issue date: 2011 Jun
- Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise.
- Authors: Michailidis Y, Karagounis LG, Terzis G, Jamurtas AZ, Spengos K, Tsoukas D, Chatzinikolaou A, Mandalidis D, Stefanetti RJ, Papassotiriou I, Athanasopoulos S, Hawley JA, Russell AP, Fatouros IG
- Issue date: 2013 Jul
- The redox-dependent regulation of satellite cells following aseptic muscle trauma (SpEED): study protocol for a randomized controlled trial.
- Authors: Papanikolaou K, Draganidis D, Chatzinikolaou A, Laschou VC, Georgakouli K, Tsimeas P, Batrakoulis A, Deli CK, Jamurtas AZ, Fatouros IG
- Issue date: 2019 Jul 31
- Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans.
- Authors: Morrison D, Hughes J, Della Gatta PA, Mason S, Lamon S, Russell AP, Wadley GD
- Issue date: 2015 Dec
- Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
- Authors: Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
- Issue date: 2022 Feb 1