2.50
Hdl Handle:
http://hdl.handle.net/2436/620757
Title:
Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review.
Authors:
Poulianiti, Konstantina P; Kaltsatou, Antonia; Mitrou, Georgia I; Jamurtas, Athanasios Z; Koutedakis, Yiannis; Maridaki, Maria; Stefanidis, Ioannis; Sakkas, Giorgos K; Karatzaferi, Christina
Abstract:
Patients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.
Citation:
Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. 2016, 2016:8598253 Oxid Med Cell Longev
Publisher:
Hindawi Publishing Corporation
Journal:
Oxidative medicine and cellular longevity
Issue Date:
2016
URI:
http://hdl.handle.net/2436/620757
DOI:
10.1155/2016/8598253
PubMed ID:
27563376
Type:
Article
Language:
en
ISSN:
1942-0900
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorPoulianiti, Konstantina Pen
dc.contributor.authorKaltsatou, Antoniaen
dc.contributor.authorMitrou, Georgia Ien
dc.contributor.authorJamurtas, Athanasios Zen
dc.contributor.authorKoutedakis, Yiannisen
dc.contributor.authorMaridaki, Mariaen
dc.contributor.authorStefanidis, Ioannisen
dc.contributor.authorSakkas, Giorgos Ken
dc.contributor.authorKaratzaferi, Christinaen
dc.date.accessioned2017-10-11T15:22:48Z-
dc.date.available2017-10-11T15:22:48Z-
dc.date.issued2016-
dc.identifier.citationSystemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. 2016, 2016:8598253 Oxid Med Cell Longeven
dc.identifier.issn1942-0900en
dc.identifier.pmid27563376-
dc.identifier.doi10.1155/2016/8598253-
dc.identifier.urihttp://hdl.handle.net/2436/620757-
dc.description.abstractPatients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.rightsArchived with thanks to Oxidative medicine and cellular longevityen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimals-
dc.subject.meshAntioxidants-
dc.subject.meshHumans-
dc.subject.meshKidney-
dc.subject.meshLipid Peroxidation-
dc.subject.meshOxidation-Reduction-
dc.subject.meshOxidative Stress-
dc.subject.meshPrognosis-
dc.subject.meshProtein Carbonylation-
dc.subject.meshReactive Oxygen Species-
dc.subject.meshRenal Insufficiency, Chronic-
dc.titleSystemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review.en
dc.typeArticleen
dc.identifier.journalOxidative medicine and cellular longevityen
dc.date.accepted2016-06-07-
rioxxterms.funderinternalen
rioxxterms.identifier.projectUOW111017YK2en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-10-11en
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