Transesterification of PHA to Oligomers Covalently Bonded with (Bio)Active Compounds Containing Either Carboxyl or Hydroxyl Functionalities

2.50
Hdl Handle:
http://hdl.handle.net/2436/620679
Title:
Transesterification of PHA to Oligomers Covalently Bonded with (Bio)Active Compounds Containing Either Carboxyl or Hydroxyl Functionalities
Authors:
Kwiecień, Iwona; Radecka, Iza; Kowalczuk, Marek; Adamus, Grażyna
Abstract:
This manuscript presents the synthesis and structural characterisation of novel biodegradable polymeric controlled-release systems of pesticides with potentially higher resistance to weather conditions in comparison to conventional forms of pesticides. Two methods for the preparation of pesticide-oligomer conjugates using the transesterification reaction were developed. The first method of obtaining conjugates, which consist of bioactive compounds with the carboxyl group and polyhydroxyalkanoates (PHAs) oligomers, is "one-pot" transesterification. In the second method, conjugates of bioactive compounds with hydroxyl group and polyhydroxyalkanoates oligomers were obtained in two-step method, through cyclic poly(3-hydroxybutyrate) oligomers. The obtained pesticide-PHA conjugates were comprehensively characterised using GPC, 1H NMR and mass spectrometry techniques. The structural characterisation of the obtained products at the molecular level with the aid of mass spectrometry confirmed that both of the synthetic strategies employed led to the formation of conjugates in which selected pesticides were covalently bonded to PHA oligomers via a hydrolysable ester bond.
Citation:
Transesterification of PHA to Oligomers Covalently Bonded with (Bio)Active Compounds Containing Either Carboxyl or Hydroxyl Functionalities 2015, 10 (3):e0120149 PLOS ONE
Journal:
PLOS ONE
Issue Date:
17-Mar-2015
URI:
http://hdl.handle.net/2436/620679
DOI:
10.1371/journal.pone.0120149
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0120149
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKwiecień, Iwonaen
dc.contributor.authorRadecka, Izaen
dc.contributor.authorKowalczuk, Mareken
dc.contributor.authorAdamus, Grażynaen
dc.date.accessioned2017-09-20T14:57:09Z-
dc.date.available2017-09-20T14:57:09Z-
dc.date.issued2015-03-17-
dc.identifier.citationTransesterification of PHA to Oligomers Covalently Bonded with (Bio)Active Compounds Containing Either Carboxyl or Hydroxyl Functionalities 2015, 10 (3):e0120149 PLOS ONEen
dc.identifier.issn1932-6203-
dc.identifier.doi10.1371/journal.pone.0120149-
dc.identifier.urihttp://hdl.handle.net/2436/620679-
dc.description.abstractThis manuscript presents the synthesis and structural characterisation of novel biodegradable polymeric controlled-release systems of pesticides with potentially higher resistance to weather conditions in comparison to conventional forms of pesticides. Two methods for the preparation of pesticide-oligomer conjugates using the transesterification reaction were developed. The first method of obtaining conjugates, which consist of bioactive compounds with the carboxyl group and polyhydroxyalkanoates (PHAs) oligomers, is "one-pot" transesterification. In the second method, conjugates of bioactive compounds with hydroxyl group and polyhydroxyalkanoates oligomers were obtained in two-step method, through cyclic poly(3-hydroxybutyrate) oligomers. The obtained pesticide-PHA conjugates were comprehensively characterised using GPC, 1H NMR and mass spectrometry techniques. The structural characterisation of the obtained products at the molecular level with the aid of mass spectrometry confirmed that both of the synthetic strategies employed led to the formation of conjugates in which selected pesticides were covalently bonded to PHA oligomers via a hydrolysable ester bond.en
dc.language.isoenen
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0120149en
dc.rightsArchived with thanks to PLOS ONEen
dc.subjectPHAen
dc.subjecttransesterificationen
dc.subjectactive oligomersen
dc.subjectpesticide-PHA conjugatesen
dc.titleTransesterification of PHA to Oligomers Covalently Bonded with (Bio)Active Compounds Containing Either Carboxyl or Hydroxyl Functionalitiesen
dc.typeArticleen
dc.identifier.journalPLOS ONEen
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