Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

2.50
Hdl Handle:
http://hdl.handle.net/2436/620554
Title:
Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride
Authors:
Zhang, Wei; She, Xuhui; Wang, Liping; Fan, Huajun; Zhou, Qing; Huang, Xiaowen; Tang, James Z
Abstract:
A novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis. With the structural analogs (amisulpride, tiapride, lidocaine and cisapride) and small molecules containing a mono-functional group (p-toluenesulfonamide, formamide and 1-methylpyrrolidine) as substrates, static adsorption, kinetic adsorption, and rebinding experiments were also performed to investigate the selective adsorption ability, kinetic characteristic, and recognition mechanism of the MIP. A serial study suggested that the highly selective recognition ability of the MIP mainly depended on binding sites provided by N-functional groups of amide and amine. Moreover, the MIP as solid-phase extractant was successfully applied to extraction of sulpiride from the mixed solution (consisted of p-toluenesulfonamide, sulfamethoxazole, sulfanilamide, p-nitroaniline, acetanilide and trimethoprim) and serum sample, and extraction recoveries ranged from 81.57% to 86.63%. The tentative tests of drug release in stimulated intestinal fluid (pH 6.8) demonstrated that the tablet with the MIP–sulpiride could obviously inhibit sulpiride release rate. Thus, ITA-based MIP is an efficient and promising alternative to solid-phase adsorbent for extraction of sulpiride and removal of interferences in biosample analysis, and could be used as a potential carrier for controlled drug release
Citation:
Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride 2017, 10 (5):475 Materials
Publisher:
MDPI
Journal:
Materials
Issue Date:
28-Apr-2017
URI:
http://hdl.handle.net/2436/620554
DOI:
10.3390/ma10050475
Additional Links:
http://www.mdpi.com/1996-1944/10/5/475
Type:
Article
Language:
en
ISSN:
1996-1944
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Weien
dc.contributor.authorShe, Xuhuien
dc.contributor.authorWang, Lipingen
dc.contributor.authorFan, Huajunen
dc.contributor.authorZhou, Qingen
dc.contributor.authorHuang, Xiaowenen
dc.contributor.authorTang, James Zen
dc.date.accessioned2017-07-04T13:55:10Z-
dc.date.available2017-07-04T13:55:10Z-
dc.date.issued2017-04-28-
dc.identifier.citationPreparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride 2017, 10 (5):475 Materialsen
dc.identifier.issn1996-1944en
dc.identifier.doi10.3390/ma10050475-
dc.identifier.urihttp://hdl.handle.net/2436/620554-
dc.description.abstractA novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis. With the structural analogs (amisulpride, tiapride, lidocaine and cisapride) and small molecules containing a mono-functional group (p-toluenesulfonamide, formamide and 1-methylpyrrolidine) as substrates, static adsorption, kinetic adsorption, and rebinding experiments were also performed to investigate the selective adsorption ability, kinetic characteristic, and recognition mechanism of the MIP. A serial study suggested that the highly selective recognition ability of the MIP mainly depended on binding sites provided by N-functional groups of amide and amine. Moreover, the MIP as solid-phase extractant was successfully applied to extraction of sulpiride from the mixed solution (consisted of p-toluenesulfonamide, sulfamethoxazole, sulfanilamide, p-nitroaniline, acetanilide and trimethoprim) and serum sample, and extraction recoveries ranged from 81.57% to 86.63%. The tentative tests of drug release in stimulated intestinal fluid (pH 6.8) demonstrated that the tablet with the MIP–sulpiride could obviously inhibit sulpiride release rate. Thus, ITA-based MIP is an efficient and promising alternative to solid-phase adsorbent for extraction of sulpiride and removal of interferences in biosample analysis, and could be used as a potential carrier for controlled drug releaseen
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttp://www.mdpi.com/1996-1944/10/5/475en
dc.rightsArchived with thanks to Materialsen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDrug releaseen
dc.subjectItaconic aciden
dc.subjectMolecularly imprinted polymeren
dc.subjectSerum analysisen
dc.subjectSulpirideen
dc.titlePreparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpirideen
dc.typeArticleen
dc.identifier.journalMaterialsen
dc.date.accepted2017-04-24-
rioxxterms.funderinternalen
rioxxterms.identifier.projectUOW040717JTen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-07-04en
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