Biocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments ? synthesis and characterization

2.50
Hdl Handle:
http://hdl.handle.net/2436/620523
Title:
Biocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments ? synthesis and characterization
Authors:
Kwiecien, Michal; Kwiecien, Iwona; Radecka, Iza ( 0000-0003-3257-8803 ) ; Kannappan, Vinodh; Morris, Mark R.; Adamus, Grazyna
Abstract:
A convenient synthetic route of poly(3HB-co-3HH-co-SEB) terpolyesters has been reported. The developed protocol consists of two steps; poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHx) oligoesterdiols were synthesized via selective reduction of biopolyesters and then via their polycondensation with sebacoyl chloride the biodegradable terpolyesters, poly(3HB-co-3HH-co-SEB), were obtained. The structure of the obtained terpolyesters was established by NMR analysis supported by mass spectrometry. Modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by incorporating units derived from sebacic acid into its chains resulted in terpolyesters with better physico-chemical properties than the starting PHBHx biopolyester. These new polyester materials have greater thermal stability than the starting biopolyester. Furthermore, the introduction of sebacic acid units to a polyester chain leads to the reduction of the glass transition temperatures of the materials and reduces the required processing temperature. A preliminary study confirmed that poly(3HB-co-3HH-co-SEB) terpolyesters can be used to create scaffolds for cell cultures in the form of a three-dimensional spatial structure. Moreover, a toxicity test of the obtained terpolyester carried out on human cells demonstrated that the novel terpolyester is not toxic to human cells in vitro.
Citation:
Biocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments ? synthesis and characterization 2017, 7 (33):20469 RSC Adv.
Publisher:
The Royal Society of Chemistry
Journal:
RSC Adv.
Issue Date:
Apr-2017
URI:
http://hdl.handle.net/2436/620523
DOI:
10.1039/C6RA27980E
Additional Links:
http://xlink.rsc.org/?DOI=C6RA27980E
Type:
Article
Language:
en
ISSN:
2046-2069
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKwiecien, Michalen
dc.contributor.authorKwiecien, Iwonaen
dc.contributor.authorRadecka, Izaen
dc.contributor.authorKannappan, Vinodhen
dc.contributor.authorMorris, Mark R.en
dc.contributor.authorAdamus, Grazynaen
dc.date.accessioned2017-06-22T11:23:02Z-
dc.date.available2017-06-22T11:23:02Z-
dc.date.issued2017-04-
dc.identifier.citationBiocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments ? synthesis and characterization 2017, 7 (33):20469 RSC Adv.en
dc.identifier.issn2046-2069en
dc.identifier.doi10.1039/C6RA27980E-
dc.identifier.urihttp://hdl.handle.net/2436/620523-
dc.description.abstractA convenient synthetic route of poly(3HB-co-3HH-co-SEB) terpolyesters has been reported. The developed protocol consists of two steps; poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHx) oligoesterdiols were synthesized via selective reduction of biopolyesters and then via their polycondensation with sebacoyl chloride the biodegradable terpolyesters, poly(3HB-co-3HH-co-SEB), were obtained. The structure of the obtained terpolyesters was established by NMR analysis supported by mass spectrometry. Modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by incorporating units derived from sebacic acid into its chains resulted in terpolyesters with better physico-chemical properties than the starting PHBHx biopolyester. These new polyester materials have greater thermal stability than the starting biopolyester. Furthermore, the introduction of sebacic acid units to a polyester chain leads to the reduction of the glass transition temperatures of the materials and reduces the required processing temperature. A preliminary study confirmed that poly(3HB-co-3HH-co-SEB) terpolyesters can be used to create scaffolds for cell cultures in the form of a three-dimensional spatial structure. Moreover, a toxicity test of the obtained terpolyester carried out on human cells demonstrated that the novel terpolyester is not toxic to human cells in vitro.en
dc.language.isoenen
dc.publisherThe Royal Society of Chemistryen
dc.relation.urlhttp://xlink.rsc.org/?DOI=C6RA27980Een
dc.rightsArchived with thanks to RSC Adv.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiocompatible terpolyestersen
dc.subjectpolyhydroxyalkanoateen
dc.subjectsebacic aciden
dc.titleBiocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments ? synthesis and characterizationen
dc.typeArticleen
dc.identifier.journalRSC Adv.en
dc.date.accepted2017-03-
rioxxterms.funderThis work was supported by Polish National Science Centre, contract DEC-2013/11/B/ST5/02222. Biological studies were funded by the Research Investment Fund, University of Wolverhampton, School of Biology, Chemistry and Forensic Science, Faculty of Science and Engineering, UKen
rioxxterms.identifier.projectDEC-2013/11/B/ST5/02222en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2017-06-22en
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