Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity

2.50
Hdl Handle:
http://hdl.handle.net/2436/620479
Title:
Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity
Authors:
Fenton, Sally A. M.; Veldhuijzen van Zanten, Jet J. C. S.; Kitas, George D.; Duda, Joan L.; Rouse, Peter C.; Yu, Chen-an; Metsios, George S.
Abstract:
Background Rheumatoid Arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD). The physical dysfunction symptomatic of RA means people living with this disease spend large periods of the day sedentary, which may further elevate their risk of CVD. The primary aim of this study was to investigate relationships between objectively assessed sedentary behaviour patterns and light physical activity (LPA) with 10-year risk of CVD. Secondary aims were to explore the role of sedentary behaviour patterns and LPA for individual CVD risk factors and functional disability in RA. The extent to which associations were independent of moderate-to-vigorous physical activity (MVPA) engagement was also examined. Methods Baseline data from a subsample of participants recruited to the Physical Activity in Rheumatoid Arthritis (PARA) study were used to answer current research questions. Sixty-one patients with RA (mean age (± SD) = 54.92 ± 12.39 years) provided a fasted blood sample and underwent physical assessments to evaluate factors associated with their cardiovascular health. Sedentary behaviour patterns (sedentary time, sedentary bouts, sedentary breaks), LPA and MVPA were measured via 7-days of accelerometry. Ten-year CVD risk was computed (Q-risk-score2), and functional disability determined via questionnaire. Results Regressions revealed significant positive associations between sedentary time and the number of sedentary bouts per day ≥20 min with 10-year CVD risk, with the reverse true for LPA participation. Associations were independent of MVPA engagement. Conclusions Promoting LPA participation and restricting sedentary bouts to <20 min may attenuate long-term CVD risk in RA, independent of MVPA engagement.
Citation:
Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity 2017, 18 (1) BMC Musculoskeletal Disorders
Publisher:
BioMed Central
Journal:
BMC Musculoskeletal Disorders
Issue Date:
29-Mar-2017
URI:
http://hdl.handle.net/2436/620479
DOI:
10.1186/s12891-017-1473-9
Additional Links:
http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-017-1473-9
Type:
Article
Language:
en
ISSN:
1471-2474
Appears in Collections:
FEHW

Full metadata record

DC FieldValue Language
dc.contributor.authorFenton, Sally A. M.en
dc.contributor.authorVeldhuijzen van Zanten, Jet J. C. S.en
dc.contributor.authorKitas, George D.en
dc.contributor.authorDuda, Joan L.en
dc.contributor.authorRouse, Peter C.en
dc.contributor.authorYu, Chen-anen
dc.contributor.authorMetsios, George S.en
dc.date.accessioned2017-05-22T13:54:06Z-
dc.date.available2017-05-22T13:54:06Z-
dc.date.issued2017-03-29-
dc.identifier.citationSedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity 2017, 18 (1) BMC Musculoskeletal Disordersen
dc.identifier.issn1471-2474en
dc.identifier.doi10.1186/s12891-017-1473-9-
dc.identifier.urihttp://hdl.handle.net/2436/620479-
dc.description.abstractBackground Rheumatoid Arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD). The physical dysfunction symptomatic of RA means people living with this disease spend large periods of the day sedentary, which may further elevate their risk of CVD. The primary aim of this study was to investigate relationships between objectively assessed sedentary behaviour patterns and light physical activity (LPA) with 10-year risk of CVD. Secondary aims were to explore the role of sedentary behaviour patterns and LPA for individual CVD risk factors and functional disability in RA. The extent to which associations were independent of moderate-to-vigorous physical activity (MVPA) engagement was also examined. Methods Baseline data from a subsample of participants recruited to the Physical Activity in Rheumatoid Arthritis (PARA) study were used to answer current research questions. Sixty-one patients with RA (mean age (± SD) = 54.92 ± 12.39 years) provided a fasted blood sample and underwent physical assessments to evaluate factors associated with their cardiovascular health. Sedentary behaviour patterns (sedentary time, sedentary bouts, sedentary breaks), LPA and MVPA were measured via 7-days of accelerometry. Ten-year CVD risk was computed (Q-risk-score2), and functional disability determined via questionnaire. Results Regressions revealed significant positive associations between sedentary time and the number of sedentary bouts per day ≥20 min with 10-year CVD risk, with the reverse true for LPA participation. Associations were independent of MVPA engagement. Conclusions Promoting LPA participation and restricting sedentary bouts to <20 min may attenuate long-term CVD risk in RA, independent of MVPA engagement.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-017-1473-9en
dc.rightsArchived with thanks to BMC Musculoskeletal Disordersen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSedentary behaviouren
dc.subjectPhysical activityen
dc.subjectRheumatoid Arthritisen
dc.subjectAccelerometryen
dc.subjectCardiovascular risken
dc.subjectInflammationen
dc.subjectPhysical Functionen
dc.titleSedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activityen
dc.typeArticleen
dc.identifier.journalBMC Musculoskeletal Disordersen
dc.date.accepted2017-03-
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW220517GMen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2017-05-22en
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