Tailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems

5.00
Hdl Handle:
http://hdl.handle.net/2436/620472
Title:
Tailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems
Authors:
Mohamed Wali, Aisha Roshan; Zhou, Jie; Ma, Shengnan; He, Yiyan; Yue, Dong; Tang, James Z; Gu, Zhongwei
Abstract:
Amphiphilic glycopolypeptide analogues have harboured great importance in the development of targeted drug delivery systems. In this study, lactosylated pullulan-graft-arginine dendrons (LP-g-G3P) was synthesized using Huisgen azide-alkyne 1,3-dipolar cycloaddition between lactosylated pullulan and generation 3 arginine dendrons bearing Pbf and Boc groups on the periphery. Hydrophilic lactosylated pullulan was selected for amphiphilic modification, aiming at specific lectin recognition. Macromolecular structure of LP-g-G3P combined alkyl, aromatic, and peptide dendritic hydrophobic moieties and was able to self-assemble spontaneously into core-shell nanoarchitectures with small particle sizes and low polydispersity in the aqueous media, which was confirmed by CAC, DLS and TEM. Furthermore, the polyaromatic anticancer drug (doxorubicin, DOX) was selectively encapsulated in the hydrophobic core through multiple interactions with the dendrons, including π-π interactions, hydrogen bonding and hydrophobic interactions. Such multiple interactions had the merits of enhanced drug loading capacity (16.89 ± 2.41%), good stability against dilution, and excellent sustained release property. The cell viability assay presented that LP-g-G3P nanoparticles had an excellent biocompatibility both in the normal and tumor cells. Moreover, LP-g-G3P/DOX nanoparticles could be effectively internalized into the hepatoma carcinoma cells and dramatically inhibited cell proliferation. Thus, this approach paves the way to develop amphiphilic and biofunctional glycopolypeptide-based drug delivery systems.
Citation:
Tailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems 2017, 525 (1):191 International Journal of Pharmaceutics
Publisher:
Elsevier
Journal:
International Journal of Pharmaceutics
Issue Date:
Jun-2017
URI:
http://hdl.handle.net/2436/620472
DOI:
10.1016/j.ijpharm.2017.04.009
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0378517317302892
Type:
Article
Language:
en
ISSN:
0378-5173
Sponsors:
the European Commission Research and Innovation (PIRSES-GA-2011-295218)
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorMohamed Wali, Aisha Roshanen
dc.contributor.authorZhou, Jieen
dc.contributor.authorMa, Shengnanen
dc.contributor.authorHe, Yiyanen
dc.contributor.authorYue, Dongen
dc.contributor.authorTang, James Zen
dc.contributor.authorGu, Zhongweien
dc.date.accessioned2017-05-10T15:17:49Z-
dc.date.available2017-05-10T15:17:49Z-
dc.date.issued2017-06-
dc.identifier.citationTailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems 2017, 525 (1):191 International Journal of Pharmaceuticsen
dc.identifier.issn0378-5173en
dc.identifier.doi10.1016/j.ijpharm.2017.04.009-
dc.identifier.urihttp://hdl.handle.net/2436/620472-
dc.description.abstractAmphiphilic glycopolypeptide analogues have harboured great importance in the development of targeted drug delivery systems. In this study, lactosylated pullulan-graft-arginine dendrons (LP-g-G3P) was synthesized using Huisgen azide-alkyne 1,3-dipolar cycloaddition between lactosylated pullulan and generation 3 arginine dendrons bearing Pbf and Boc groups on the periphery. Hydrophilic lactosylated pullulan was selected for amphiphilic modification, aiming at specific lectin recognition. Macromolecular structure of LP-g-G3P combined alkyl, aromatic, and peptide dendritic hydrophobic moieties and was able to self-assemble spontaneously into core-shell nanoarchitectures with small particle sizes and low polydispersity in the aqueous media, which was confirmed by CAC, DLS and TEM. Furthermore, the polyaromatic anticancer drug (doxorubicin, DOX) was selectively encapsulated in the hydrophobic core through multiple interactions with the dendrons, including π-π interactions, hydrogen bonding and hydrophobic interactions. Such multiple interactions had the merits of enhanced drug loading capacity (16.89 ± 2.41%), good stability against dilution, and excellent sustained release property. The cell viability assay presented that LP-g-G3P nanoparticles had an excellent biocompatibility both in the normal and tumor cells. Moreover, LP-g-G3P/DOX nanoparticles could be effectively internalized into the hepatoma carcinoma cells and dramatically inhibited cell proliferation. Thus, this approach paves the way to develop amphiphilic and biofunctional glycopolypeptide-based drug delivery systems.en
dc.description.sponsorshipthe European Commission Research and Innovation (PIRSES-GA-2011-295218)en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0378517317302892en
dc.rightsArchived with thanks to International Journal of Pharmaceuticsen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectamphiphilic polysaccharideen
dc.subjectpeptide dendronsen
dc.subjectglycopolypeptideen
dc.subjectsustained release,en
dc.subjecttargeted drug deliveryen
dc.titleTailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systemsen
dc.typeArticleen
dc.identifier.journalInternational Journal of Pharmaceuticsen
dc.date.accepted2017-04-
rioxxterms.funderthe European Commission Research and Innovationen
rioxxterms.identifier.projectUoW100517JTen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-06-15en
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