Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

2.50
Hdl Handle:
http://hdl.handle.net/2436/620372
Title:
Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications
Authors:
Khalil, Ibrahim; Burns, Alan; Radecka, Iza ( 0000-0003-3257-8803 ) ; Kowalczuk, Marek; Khalaf, Tamara; Adamus, Grazyna; Johnston, Brian; Khechara, Martin
Abstract:
Abstract: In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.
Citation:
Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications 2017, 18 (2):313 International Journal of Molecular Sciences
Journal:
International Journal of Molecular Sciences, 2017, 18(2), 313
Issue Date:
2-Feb-2017
URI:
http://hdl.handle.net/2436/620372
DOI:
10.3390/ijms18020313
Additional Links:
http://www.mdpi.com/1422-0067/18/2/313
Type:
Article
Language:
en
ISSN:
1661-6596
Sponsors:
Iraqi cultural attaché
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKhalil, Ibrahimen
dc.contributor.authorBurns, Alanen
dc.contributor.authorRadecka, Izaen
dc.contributor.authorKowalczuk, Mareken
dc.contributor.authorKhalaf, Tamaraen
dc.contributor.authorAdamus, Grazynaen
dc.contributor.authorJohnston, Brianen
dc.contributor.authorKhechara, Martinen
dc.date.accessioned2017-02-07T14:36:22Z-
dc.date.available2017-02-07T14:36:22Z-
dc.date.issued2017-02-02-
dc.identifier.citationBacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications 2017, 18 (2):313 International Journal of Molecular Sciencesen
dc.identifier.issn1661-6596en
dc.identifier.doi10.3390/ijms18020313-
dc.identifier.urihttp://hdl.handle.net/2436/620372-
dc.description.abstractAbstract: In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.en
dc.description.sponsorshipIraqi cultural attachéen
dc.language.isoenen
dc.relation.urlhttp://www.mdpi.com/1422-0067/18/2/313en
dc.rightsArchived with thanks to International Journal of Molecular Sciencesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectγ-PGAen
dc.subjectantimicrobialen
dc.subjectdrug delivery systemen
dc.titleBacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applicationsen
dc.typeArticleen
dc.identifier.journalInternational Journal of Molecular Sciences, 2017, 18(2), 313en
dc.date.accepted2017-02-
rioxxterms.funderIraqi cultural attachéen
rioxxterms.identifier.projectUoW070217IRen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2017-02-07en
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