LDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men.

2.50
Hdl Handle:
http://hdl.handle.net/2436/620364
Title:
LDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men.
Authors:
O'donovan, G; McEneny, J; Kearney, E M; Owen, A; Nevill, Alan M.; Woolf-May, K; Bird, S R
Abstract:
Habitual exercisers enjoy considerable protection from coronary heart disease (CHD). Often, however, only modest differences in traditional CHD risk factors are apparent between habitual exercisers and their sedentary counterparts. For this reason, there is increasing interest in novel predictors of CHD, such as a preponderance of small, dense low-density lipoprotein (LDL) particles. Polyacrylamide gel electrophoresis was used to separate lipoprotein subfractions in 32 lean exercisers, 36 lean sedentary men and 21 obese sedentary men aged 30 - 45 years. Well-validated equations were used to determine LDL concentration and peak particle diameter. Waist girth was used to identify lean (< 100 cm) and obese (>or= 100 cm) individuals. LDL concentration was lower in lean exercisers than in lean sedentary men (2.64 +/- 0.44 vs. 3.76 +/- 0.79 mmol . l (-1), p < 0.001), suggesting that habitual exercise influences this risk factor. In contrast, there were no significant differences in LDL peak particle diameter between lean exercisers, lean sedentary men and obese sedentary men (27.92 +/- 0.67, 28.09 +/- 0.62 and 27.77 +/- 0.77 nm, respectively). In multiple linear regression analysis, triglyceride concentration was the only significant predictor of LDL PPD. These data suggest that habitual exercise influences LDL concentration but does not influence LDL particle size in men aged 30 - 45 years.
Citation:
LDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men. 2007, 28 (8):644-9 Int J Sports Med
Publisher:
Thieme
Journal:
International journal of sports medicine
Issue Date:
Aug-2007
URI:
http://hdl.handle.net/2436/620364
DOI:
10.1055/s-2007-964892
PubMed ID:
17436197
Type:
Article
Language:
en
ISSN:
0172-4622; 0172-4622
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorO'donovan, Gen
dc.contributor.authorMcEneny, Jen
dc.contributor.authorKearney, E Men
dc.contributor.authorOwen, Aen
dc.contributor.authorNevill, Alan M.en
dc.contributor.authorWoolf-May, Ken
dc.contributor.authorBird, S Ren
dc.date.accessioned2017-02-02T12:44:20Z-
dc.date.available2017-02-02T12:44:20Z-
dc.date.issued2007-08-
dc.identifier.citationLDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men. 2007, 28 (8):644-9 Int J Sports Meden
dc.identifier.issn0172-4622-
dc.identifier.issn0172-4622-
dc.identifier.pmid17436197-
dc.identifier.doi10.1055/s-2007-964892-
dc.identifier.urihttp://hdl.handle.net/2436/620364-
dc.description.abstractHabitual exercisers enjoy considerable protection from coronary heart disease (CHD). Often, however, only modest differences in traditional CHD risk factors are apparent between habitual exercisers and their sedentary counterparts. For this reason, there is increasing interest in novel predictors of CHD, such as a preponderance of small, dense low-density lipoprotein (LDL) particles. Polyacrylamide gel electrophoresis was used to separate lipoprotein subfractions in 32 lean exercisers, 36 lean sedentary men and 21 obese sedentary men aged 30 - 45 years. Well-validated equations were used to determine LDL concentration and peak particle diameter. Waist girth was used to identify lean (< 100 cm) and obese (>or= 100 cm) individuals. LDL concentration was lower in lean exercisers than in lean sedentary men (2.64 +/- 0.44 vs. 3.76 +/- 0.79 mmol . l (-1), p < 0.001), suggesting that habitual exercise influences this risk factor. In contrast, there were no significant differences in LDL peak particle diameter between lean exercisers, lean sedentary men and obese sedentary men (27.92 +/- 0.67, 28.09 +/- 0.62 and 27.77 +/- 0.77 nm, respectively). In multiple linear regression analysis, triglyceride concentration was the only significant predictor of LDL PPD. These data suggest that habitual exercise influences LDL concentration but does not influence LDL particle size in men aged 30 - 45 years.en
dc.language.isoenen
dc.publisherThiemeen
dc.rightsArchived with thanks to International journal of sports medicineen
dc.subjectlow‐density lipoprotein particle sizeen
dc.subjectexerciseen
dc.subjectwaist girthen
dc.subjectcoronary heart diseaseen
dc.subject.meshAbdominal Fat-
dc.subject.meshAdult-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshExercise-
dc.subject.meshHumans-
dc.subject.meshLipoproteins, LDL-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity-
dc.subject.meshParticle Size-
dc.subject.meshThinness-
dc.titleLDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men.en
dc.typeArticleen
dc.identifier.journalInternational journal of sports medicineen

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