Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels.

2.50
Hdl Handle:
http://hdl.handle.net/2436/620316
Title:
Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels.
Authors:
Gupta, Abhishek; Low, Wan Li; Britland, Stephen T; Mohd Amin, Mohd Cairul Iqbal; Martin, Claire; Radecka, Iza ( 0000-0003-3257-8803 )
Abstract:
Wounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.
Citation:
Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels. 2016:1-10 J Microencapsul
Publisher:
Taylor & Francis Online
Journal:
Journal of microencapsulation
Issue Date:
28-Nov-2016
URI:
http://hdl.handle.net/2436/620316
DOI:
10.1080/02652048.2016.1253796
PubMed ID:
27781557
Additional Links:
http://www.tandfonline.com/doi/abs/10.1080/02652048.2016.1253796?journalCode=imnc20
Type:
Article
Language:
en
ISSN:
0265-2048
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorGupta, Abhisheken
dc.contributor.authorLow, Wan Lien
dc.contributor.authorBritland, Stephen Ten
dc.contributor.authorMohd Amin, Mohd Cairul Iqbalen
dc.contributor.authorMartin, Claireen
dc.contributor.authorRadecka, Izaen
dc.date.accessioned2016-12-19T16:03:07Z-
dc.date.available2016-12-19T16:03:07Z-
dc.date.issued2016-11-28-
dc.identifier.citationCharacterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels. 2016:1-10 J Microencapsulen
dc.identifier.issn0265-2048en
dc.identifier.pmid27781557-
dc.identifier.doi10.1080/02652048.2016.1253796-
dc.identifier.urihttp://hdl.handle.net/2436/620316-
dc.description.abstractWounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.en
dc.language.isoenen
dc.publisherTaylor & Francis Onlineen
dc.relation.urlhttp://www.tandfonline.com/doi/abs/10.1080/02652048.2016.1253796?journalCode=imnc20en
dc.rightsArchived with thanks to Journal of microencapsulationen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntimicrobialen
dc.subjectbacterial celluloseen
dc.subjecthydrogelen
dc.subjectsilveren
dc.subjectsilver zeoliteen
dc.titleCharacterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels.en
dc.typeArticleen
dc.identifier.journalJournal of microencapsulationen
dc.date.accepted2016-10-
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW191216IRen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2017-11-30en
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