Surface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassays

2.50
Hdl Handle:
http://hdl.handle.net/2436/620258
Title:
Surface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassays
Authors:
Schiller, T.L.; Blakey, I.; Fredericks, P.M.; Keddie, Daniel ( 0000-0003-3422-2034 )
Abstract:
The preparation of biotinylated, self-assembled polymer stabilized gold nanoparticle hybrids encoded with a SERS active compound is described. The polymers used for nanoparticle stabilization are carefully designed for this purpose and are synthesized by the RAFT polymerization process, as the thiocarbonylthio end group provides a functional handle for anchoring the polymers to the gold surface. Functionalised biotin moieties are attached to the hybrid nanoparticles via Cu-catalyzed azide-alkyne cycloaddition. Binding of the biotinylated hybrid nanoparticles to streptavidin was confirmed by nanoparticle detection and identification by the SERS spectrum of the surface-bound SERS active compound, quinolinethiol. This investigation includes the requisites that constitute a bioassay, demonstrating the potential of polymer-coated hybrid nanoparticles for this purpose.
Citation:
Surface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassays 2016 European Polymer Journal
Publisher:
Elsevier
Journal:
European Polymer Journal
Issue Date:
Sep-2016
URI:
http://hdl.handle.net/2436/620258
DOI:
10.1016/j.eurpolymj.2016.08.032
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0014305716309880
Type:
Article
Language:
en
ISSN:
0014-3057
Sponsors:
Australian Reasearch Council
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorSchiller, T.L.en
dc.contributor.authorBlakey, I.en
dc.contributor.authorFredericks, P.M.en
dc.contributor.authorKeddie, Danielen
dc.date.accessioned2016-11-04T14:23:29Z-
dc.date.available2016-11-04T14:23:29Z-
dc.date.issued2016-09-
dc.identifier.citationSurface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassays 2016 European Polymer Journalen
dc.identifier.issn0014-3057en
dc.identifier.doi10.1016/j.eurpolymj.2016.08.032-
dc.identifier.urihttp://hdl.handle.net/2436/620258-
dc.description.abstractThe preparation of biotinylated, self-assembled polymer stabilized gold nanoparticle hybrids encoded with a SERS active compound is described. The polymers used for nanoparticle stabilization are carefully designed for this purpose and are synthesized by the RAFT polymerization process, as the thiocarbonylthio end group provides a functional handle for anchoring the polymers to the gold surface. Functionalised biotin moieties are attached to the hybrid nanoparticles via Cu-catalyzed azide-alkyne cycloaddition. Binding of the biotinylated hybrid nanoparticles to streptavidin was confirmed by nanoparticle detection and identification by the SERS spectrum of the surface-bound SERS active compound, quinolinethiol. This investigation includes the requisites that constitute a bioassay, demonstrating the potential of polymer-coated hybrid nanoparticles for this purpose.en
dc.description.sponsorshipAustralian Reasearch Councilen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014305716309880en
dc.rightsArchived with thanks to European Polymer Journalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSERSen
dc.subjectHybrid polymer-gold nanoparticlesen
dc.subjectBioassaysen
dc.subjectRAFT polymerizationen
dc.titleSurface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassaysen
dc.typeArticleen
dc.identifier.journalEuropean Polymer Journalen
dc.date.accepted2016-08-
rioxxterms.funderAustralian Reasearch Councilen
rioxxterms.identifier.project041116DKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-03-31en
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