Ionically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applications

2.50
Hdl Handle:
http://hdl.handle.net/2436/614074
Title:
Ionically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applications
Authors:
Kenward, M.A.; Amin, Mohd; Martin, Claire; Low, Wan Li ( 0000-0002-8735-3399 )
Abstract:
The emerging problems posed by antibiotic resistance complicate the treatment regime required for wound infections and are driving the need to develop more effective methods of wound management. There is growing interest in the use of alternative, broad spectrum, pre-antibiotic antimicrobial agents such as essential oils (e.g., tea tree oil, TTO) and metal ions (e.g., silver, Ag+). Both TTO and Ag+ have broad spectrum antimicrobial activity and act on multiple target sites, hence reducing the likelihood of developing resistance. Combining such agents with responsive, controlled release delivery systems such as hydrogels may enhance microbiocidal activity and promote wound healing. The advantages of using chitosan to formulate the hydrogels include its biocompatible, mucoadhesive and controlled release properties. In this study, hydrogels loaded with TTO and Ag+ exhibited antimicrobial activity against P. aeruginosa, S. aureus and C. albicans. Combining TTO and Ag+ into the hydrogel further improved antimicrobial activity by lowering the effective concentrations required, respectively. This has obvious advantages for reducing the potential toxic effects on the healthy tissues surrounding the wound. These studies highlight the feasibility of delivering lower effective concentrations of antimicrobial agents such as TTO and Ag+ in ionically crosslinked chitosan hydrogels to treat common wound-infecting pathogens.
Citation:
Ionically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applications 2016, 3 (1):8 Medicines
Publisher:
MDPI AG, Basel, Switzerland
Journal:
Medicines
Issue Date:
1-Mar-2016
URI:
http://hdl.handle.net/2436/614074
DOI:
10.3390/medicines3010008
Additional Links:
http://www.mdpi.com/2305-6320/3/1/8
Type:
Article
Language:
en
ISSN:
2305-6320
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKenward, M.A.en
dc.contributor.authorAmin, Mohden
dc.contributor.authorMartin, Claireen
dc.contributor.authorLow, Wan Lien
dc.date.accessioned2016-06-22T11:42:53Zen
dc.date.available2016-06-22T11:42:53Zen
dc.date.issued2016-03-01en
dc.identifier.citationIonically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applications 2016, 3 (1):8 Medicinesen
dc.identifier.issn2305-6320en
dc.identifier.doi10.3390/medicines3010008en
dc.identifier.urihttp://hdl.handle.net/2436/614074en
dc.description.abstractThe emerging problems posed by antibiotic resistance complicate the treatment regime required for wound infections and are driving the need to develop more effective methods of wound management. There is growing interest in the use of alternative, broad spectrum, pre-antibiotic antimicrobial agents such as essential oils (e.g., tea tree oil, TTO) and metal ions (e.g., silver, Ag+). Both TTO and Ag+ have broad spectrum antimicrobial activity and act on multiple target sites, hence reducing the likelihood of developing resistance. Combining such agents with responsive, controlled release delivery systems such as hydrogels may enhance microbiocidal activity and promote wound healing. The advantages of using chitosan to formulate the hydrogels include its biocompatible, mucoadhesive and controlled release properties. In this study, hydrogels loaded with TTO and Ag+ exhibited antimicrobial activity against P. aeruginosa, S. aureus and C. albicans. Combining TTO and Ag+ into the hydrogel further improved antimicrobial activity by lowering the effective concentrations required, respectively. This has obvious advantages for reducing the potential toxic effects on the healthy tissues surrounding the wound. These studies highlight the feasibility of delivering lower effective concentrations of antimicrobial agents such as TTO and Ag+ in ionically crosslinked chitosan hydrogels to treat common wound-infecting pathogens.en
dc.language.isoenen
dc.publisherMDPI AG, Basel, Switzerlanden
dc.relation.urlhttp://www.mdpi.com/2305-6320/3/1/8en
dc.rightsArchived with thanks to Medicinesen
dc.subjectsilveren
dc.subjecttea tree oilen
dc.subjecthydrogelsen
dc.subjectchitosanen
dc.subjectwound managementen
dc.subjectantimicrobial activityen
dc.titleIonically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applicationsen
dc.typeArticleen
dc.identifier.journalMedicinesen
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