Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans.

2.50
Hdl Handle:
http://hdl.handle.net/2436/613212
Title:
Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans.
Authors:
Kenward, M A; Hill, D J; Martin, C; Low, Wan Li ( 0000-0002-8735-3399 )
Abstract:
Liposomes are biocompatible, biodegradable, controlled delivery systems with the ability to encapsulate both lipophilic and hydrophilic compounds, including metal ions. Liposome encapsulated Ag(+) (lipo-Ag(+)), prepared by reverse-phase evaporation, was used as a controlled delivery system against Candida albicans. Characterisation of the lipo-Ag(+) indicated that the multilamellar vesicles with diameters ranging between ≈ 0.5 and 5.0 μm showed potential as a controlled delivery system to consistently deliver Ag(+) to C. albicans. Results from inductively coupled plasma (ICP) analysis showed higher association of cell bound Ag(+) at 15 mins post exposure when compared to unencapsulated Ag(+). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicate detrimental effects of Ag(+) on C. albicans cell structure. These effects along with the ICP results also correlate with previously reported time kill experiment observations.
Citation:
Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans. 2016, 33 (2):146-52 J Microencapsul
Publisher:
Taylor & Francis
Journal:
Journal of microencapsulation
Issue Date:
Jan-2016
URI:
http://hdl.handle.net/2436/613212
DOI:
10.3109/02652048.2015.1134692
PubMed ID:
26786597
Type:
Article
Language:
en
ISSN:
1464-5246
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKenward, M Aen
dc.contributor.authorHill, D Jen
dc.contributor.authorMartin, Cen
dc.contributor.authorLow, Wan Lien
dc.date.accessioned2016-06-15T15:39:05Zen
dc.date.available2016-06-15T15:39:05Zen
dc.date.issued2016-01en
dc.identifier.citationCharacterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans. 2016, 33 (2):146-52 J Microencapsulen
dc.identifier.issn1464-5246en
dc.identifier.pmid26786597en
dc.identifier.doi10.3109/02652048.2015.1134692en
dc.identifier.urihttp://hdl.handle.net/2436/613212en
dc.description.abstractLiposomes are biocompatible, biodegradable, controlled delivery systems with the ability to encapsulate both lipophilic and hydrophilic compounds, including metal ions. Liposome encapsulated Ag(+) (lipo-Ag(+)), prepared by reverse-phase evaporation, was used as a controlled delivery system against Candida albicans. Characterisation of the lipo-Ag(+) indicated that the multilamellar vesicles with diameters ranging between ≈ 0.5 and 5.0 μm showed potential as a controlled delivery system to consistently deliver Ag(+) to C. albicans. Results from inductively coupled plasma (ICP) analysis showed higher association of cell bound Ag(+) at 15 mins post exposure when compared to unencapsulated Ag(+). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicate detrimental effects of Ag(+) on C. albicans cell structure. These effects along with the ICP results also correlate with previously reported time kill experiment observations.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.rightsArchived with thanks to Journal of microencapsulationen
dc.subjectCandida albicansen
dc.subjectcontrolled releaseen
dc.subjectliposomesen
dc.subjectsilveren
dc.subjectwound managementen
dc.titleCharacterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans.en
dc.typeArticleen
dc.identifier.journalJournal of microencapsulationen

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