On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a review

2.50
Hdl Handle:
http://hdl.handle.net/2436/612012
Title:
On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a review
Authors:
Kaialy, Waseem ( 0000-0001-7736-4329 )
Abstract:
Blending drug and carrier powders to produce homogeneous drug–carrier adhesive mixtures is a key step in the production of dry powder inhaler (DPI) formulations. Although the blending conditions can result in different conclusions or probably change the outcome of a study entirely if being selected differently, there is a scarcity of data on the influence of blending processes on the physicochemical properties of bulk powder formulations and the follow-on effects on DPI performance. This paper provides an overview of the interactions between variables related to blending conditions (e.g. blending equipment, time, speed and sequence as well as environmental humidity) and powder physicochemical properties (e.g. size distribution, shape distribution, density, anomeric composition, electrostatic charge, surface, and bulk properties), and their effects on the performance of adhesive mixtures for inhalation in terms of drug content homogeneity, drug–carrier adhesion, and drug aerosolisation behaviour. The relevance of carrier payload, batch size and segregation were also discussed. Challenges and future directions were identified. This review therefore contributes towards a better understanding of the blending process, powder physicochemical properties, and their interlinked effects on the fundamental understanding of adhesive mixtures for inhalation. The knowledge gained is essential to ensure optimum blending and thereby controlled functionality of DPIs.
Citation:
On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a review 2016 Advances in Colloid and Interface Science
Publisher:
Elsevier
Journal:
Advances in Colloid and Interface Science
Issue Date:
May-2016
URI:
http://hdl.handle.net/2436/612012
DOI:
10.1016/j.cis.2016.05.014
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0001868616300756
Type:
Article
Language:
en
ISSN:
0001-8686
EISSN:
1873-3727
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.date.accessioned2016-06-07T14:43:17Zen
dc.date.available2016-06-07T14:43:17Zen
dc.date.issued2016-05en
dc.identifier.citationOn the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a review 2016 Advances in Colloid and Interface Scienceen
dc.identifier.issn0001-8686en
dc.identifier.doi10.1016/j.cis.2016.05.014en
dc.identifier.urihttp://hdl.handle.net/2436/612012en
dc.description.abstractBlending drug and carrier powders to produce homogeneous drug–carrier adhesive mixtures is a key step in the production of dry powder inhaler (DPI) formulations. Although the blending conditions can result in different conclusions or probably change the outcome of a study entirely if being selected differently, there is a scarcity of data on the influence of blending processes on the physicochemical properties of bulk powder formulations and the follow-on effects on DPI performance. This paper provides an overview of the interactions between variables related to blending conditions (e.g. blending equipment, time, speed and sequence as well as environmental humidity) and powder physicochemical properties (e.g. size distribution, shape distribution, density, anomeric composition, electrostatic charge, surface, and bulk properties), and their effects on the performance of adhesive mixtures for inhalation in terms of drug content homogeneity, drug–carrier adhesion, and drug aerosolisation behaviour. The relevance of carrier payload, batch size and segregation were also discussed. Challenges and future directions were identified. This review therefore contributes towards a better understanding of the blending process, powder physicochemical properties, and their interlinked effects on the fundamental understanding of adhesive mixtures for inhalation. The knowledge gained is essential to ensure optimum blending and thereby controlled functionality of DPIs.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0001868616300756en
dc.rightsArchived with thanks to Advances in Colloid and Interface Scienceen
dc.subjectAdhesive mixturesen
dc.subjectCarrier-based dry powder inhaler formulationsen
dc.subjectHomogeneityen
dc.subjectInterparticulate forcesen
dc.subjectMixersen
dc.subjectMicromeritic and bulk properties.en
dc.titleOn the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a reviewen
dc.typeArticleen
dc.identifier.eissn1873-3727en
dc.identifier.journalAdvances in Colloid and Interface Scienceen
dc.date.accepted2016-05-28en
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW070616WKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2017-06-04en
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