Influence of mannitol concentration on the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol.

2.50
Hdl Handle:
http://hdl.handle.net/2436/611580
Title:
Influence of mannitol concentration on the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol.
Authors:
Kaialy, Waseem ( 0000-0001-7736-4329 ) ; Khan, Usman; Mawlud, Shadan
Abstract:
Mannitol is a pharmaceutical excipient that is receiving increased popularity in solid dosage forms. The aim of this study was to provide comparative evaluation on the effect of mannitol concentration on the physicochemical, mechanical, and pharmaceutical properties of lyophilised mannitol. The results showed that the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol powders are strong functions of mannitol concentration. By decreasing mannitol concentration, the true density, bulk density, cohesivity, flowability, netcharge-to-mass ratio, and relative degree of crystallinity of LM were decreased, whereas the breakability, size distribution, and size homogeneity of lyophilised mannitol particles were increased. The mechanical properties of lyophilised mannitol tablets improved with decreasing mannitol concentration. The use of lyophilised mannitol has profoundly improved the dissolution rate of indomethacin from tablets in comparison to commercial mannitol. This improvement exhibited an increasing trend with decreasing mannitol concentration. In conclusion, mannitols lyophilised from lower concentrations are more desirable in tableting than mannitols from higher concentrations due to their better mechanical and dissolution properties.
Citation:
Influence of mannitol concentration on the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol. 2016: Int J Pharm
Publisher:
Elsevier
Journal:
International journal of pharmaceutics, Volume 404, 20 June 2016, Pages 48–59
Issue Date:
27-May-2016
URI:
http://hdl.handle.net/2436/611580
DOI:
10.1016/j.ijpharm.2016.05.052
PubMed ID:
27242312
Type:
Article
Language:
en
ISSN:
0378-5173
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorKhan, Usmanen
dc.contributor.authorMawlud, Shadanen
dc.date.accessioned2016-06-02T15:16:53Zen
dc.date.available2016-06-02T15:16:53Zen
dc.date.issued2016-05-27en
dc.identifier.citationInfluence of mannitol concentration on the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol. 2016: Int J Pharmen
dc.identifier.issn0378-5173en
dc.identifier.pmid27242312en
dc.identifier.doi10.1016/j.ijpharm.2016.05.052en
dc.identifier.urihttp://hdl.handle.net/2436/611580en
dc.description.abstractMannitol is a pharmaceutical excipient that is receiving increased popularity in solid dosage forms. The aim of this study was to provide comparative evaluation on the effect of mannitol concentration on the physicochemical, mechanical, and pharmaceutical properties of lyophilised mannitol. The results showed that the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol powders are strong functions of mannitol concentration. By decreasing mannitol concentration, the true density, bulk density, cohesivity, flowability, netcharge-to-mass ratio, and relative degree of crystallinity of LM were decreased, whereas the breakability, size distribution, and size homogeneity of lyophilised mannitol particles were increased. The mechanical properties of lyophilised mannitol tablets improved with decreasing mannitol concentration. The use of lyophilised mannitol has profoundly improved the dissolution rate of indomethacin from tablets in comparison to commercial mannitol. This improvement exhibited an increasing trend with decreasing mannitol concentration. In conclusion, mannitols lyophilised from lower concentrations are more desirable in tableting than mannitols from higher concentrations due to their better mechanical and dissolution properties.en
dc.languageENGen
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to International journal of pharmaceuticsen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDissolutionen
dc.subjectFreeze-drying (lyophilisation)en
dc.subjectIndomethacinen
dc.subjectMannitolen
dc.subjectMolecularen
dc.subjectmicromeritic and bulk propertiesen
dc.subjectTabletsen
dc.titleInfluence of mannitol concentration on the physicochemical, mechanical and pharmaceutical properties of lyophilised mannitol.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceutics, Volume 404, 20 June 2016, Pages 48–59en
dc.date.accepted2016-05-27en
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW020616WKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2017-06-19en

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