Factors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional study

2.50
Hdl Handle:
http://hdl.handle.net/2436/611234
Title:
Factors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional study
Authors:
Osailan, Ahmad; Metsios, George S.; Rouse, Peter C.; Ntoumanis, Nikos; Duda, Joan L.; Kitas, George D.; Veldhuijzen van Zanten, Jet J. C. S.
Abstract:
Background Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) with poor parasympathetic function being implicated as an underlying factor. Factors related to parasympathetic function, commonly assessed by heart rate recovery (HRR) following maximal exercise, are currently not known in RA. We aimed to explore the association between HRR with CVD risk factors, inflammatory markers, and wellbeing in patients with RA. Methods Ninety-six RA patients (54.4 ± 12.6 years, 68 % women) completed a treadmill exercise test, during which heart rate (HR) was monitored. HRR1 and HRR2 were defined as the absolute change from HR peak to HRR 1 min post HR peak and 2 min post HR peak, respectively. Cardiorespiratory fitness, CVD risk factors, and serological markers of inflammation were measured in all patients. The Framingham Risk Score (FRS) was used as an assessment of global risk for CVD events, and wellbeing was assessed by questionnaires. Results Mean HRR1 and HRR2 were 29.1 ± 13.2 bpm and 46.4 ± 15.3 bpm, respectively. CVD risk factors as well as most inflammatory markers and measures of wellbeing were inversely correlated with HRR1 and HRR2. Multivariate regression analyses revealed that 27.9 % of the variance in HRR1 and 37.9 % of the variance in HRR2 was explained collectively by CVD risk factors, measures of inflammation, and wellbeing (p = 0.009, p = 0.001 respectively), however no individual measure was independently associated with HRR1 or HRR2. Conclusion Parasympathetic activation was associated with overall CVD risk, arthritis-related burden and wellbeing in patients with RA.
Citation:
Factors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional study 2016, 16 (1) BMC Cardiovascular Disorders
Journal:
BMC Cardiovascular Disorders
Issue Date:
10-May-2016
URI:
http://hdl.handle.net/2436/611234
DOI:
10.1186/s12872-016-0264-9
Additional Links:
http://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-016-0264-9
Type:
Article
Language:
en
ISSN:
1471-2261
Appears in Collections:
FEHW

Full metadata record

DC FieldValue Language
dc.contributor.authorOsailan, Ahmaden
dc.contributor.authorMetsios, George S.en
dc.contributor.authorRouse, Peter C.en
dc.contributor.authorNtoumanis, Nikosen
dc.contributor.authorDuda, Joan L.en
dc.contributor.authorKitas, George D.en
dc.contributor.authorVeldhuijzen van Zanten, Jet J. C. S.en
dc.date.accessioned2016-05-31T11:34:08Zen
dc.date.available2016-05-31T11:34:08Zen
dc.date.issued2016-05-10en
dc.identifier.citationFactors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional study 2016, 16 (1) BMC Cardiovascular Disordersen
dc.identifier.issn1471-2261en
dc.identifier.doi10.1186/s12872-016-0264-9en
dc.identifier.urihttp://hdl.handle.net/2436/611234en
dc.description.abstractBackground Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) with poor parasympathetic function being implicated as an underlying factor. Factors related to parasympathetic function, commonly assessed by heart rate recovery (HRR) following maximal exercise, are currently not known in RA. We aimed to explore the association between HRR with CVD risk factors, inflammatory markers, and wellbeing in patients with RA. Methods Ninety-six RA patients (54.4 ± 12.6 years, 68 % women) completed a treadmill exercise test, during which heart rate (HR) was monitored. HRR1 and HRR2 were defined as the absolute change from HR peak to HRR 1 min post HR peak and 2 min post HR peak, respectively. Cardiorespiratory fitness, CVD risk factors, and serological markers of inflammation were measured in all patients. The Framingham Risk Score (FRS) was used as an assessment of global risk for CVD events, and wellbeing was assessed by questionnaires. Results Mean HRR1 and HRR2 were 29.1 ± 13.2 bpm and 46.4 ± 15.3 bpm, respectively. CVD risk factors as well as most inflammatory markers and measures of wellbeing were inversely correlated with HRR1 and HRR2. Multivariate regression analyses revealed that 27.9 % of the variance in HRR1 and 37.9 % of the variance in HRR2 was explained collectively by CVD risk factors, measures of inflammation, and wellbeing (p = 0.009, p = 0.001 respectively), however no individual measure was independently associated with HRR1 or HRR2. Conclusion Parasympathetic activation was associated with overall CVD risk, arthritis-related burden and wellbeing in patients with RA.en
dc.language.isoenen
dc.relation.urlhttp://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-016-0264-9en
dc.rightsArchived with thanks to BMC Cardiovascular Disordersen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRheumatoid arthritisen
dc.subjectParasympathetic functionen
dc.subjectAutonomic functionen
dc.subjectCardiovascular risken
dc.subjectExercise testingen
dc.titleFactors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional studyen
dc.typeArticleen
dc.identifier.journalBMC Cardiovascular Disordersen
dc.date.accepted2016-05-01en
rioxxterms.funderMedical Research Councilen
rioxxterms.identifier.projectN/Aen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2016-05-10en
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