Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process.

2.50
Hdl Handle:
http://hdl.handle.net/2436/610896
Title:
Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process.
Authors:
Rudrangi, Shashi Ravi Suman; Kaialy, Waseem ( 0000-0001-7736-4329 ) ; Ghori, Muhammad U; Trivedi, Vivek; Snowden, Martin J; Alexander, Bruce David
Abstract:
The aim of this study was to enhance the apparent solubility and dissolution properties of flurbiprofen through inclusion complexation with cyclodextrins. Especially, the efficacy of supercritical fluid technology as a preparative technique for the preparation of flurbiprofen-methyl-β-cyclodextrin inclusion complexes was evaluated. The complexes were prepared by supercritical carbon dioxide processing and were evaluated by solubility, differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy, practical yield, drug content estimation and in vitro dissolution studies. Computational molecular docking studies were conducted to study the possibility of molecular arrangement of inclusion complexes between flurbiprofen and methyl-β-cyclodextrin. The studies support the formation of stable molecular inclusion complexes between the drug and cyclodextrin in a 1:1 stoichiometry. In vitro dissolution studies showed that the dissolution properties of flurbiprofen were significantly enhanced by the binary mixtures prepared by supercritical carbon dioxide processing. The amount of flurbiprofen dissolved into solution alone was very low with 1.11 ± 0.09% dissolving at the end of 60 min, while the binary mixtures processed by supercritical carbon dioxide at 45 °C and 200 bar released 99.39 ± 2.34% of the drug at the end of 30 min. All the binary mixtures processed by supercritical carbon dioxide at 45 °C exhibited a drug release of more than 80% within the first 10 min irrespective of the pressure employed. The study demonstrated the single step, organic solvent-free supercritical carbon dioxide process as a promising approach for the preparation of inclusion complexes between flurbiprofen and methyl-β-cyclodextrin in solid-state.
Citation:
Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process. 2016: Eur J Pharm Biopharm
Publisher:
Elsevir
Journal:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Issue Date:
6-May-2016
URI:
http://hdl.handle.net/2436/610896
DOI:
10.1016/j.ejpb.2016.04.024
PubMed ID:
27163245
Additional Links:
http://dx.doi.org/10.1016/j.ejpb.2016.04.024
Type:
Article
Language:
en
ISSN:
0939-6411
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorRudrangi, Shashi Ravi Sumanen
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorGhori, Muhammad Uen
dc.contributor.authorTrivedi, Viveken
dc.contributor.authorSnowden, Martin Jen
dc.contributor.authorAlexander, Bruce Daviden
dc.date.accessioned2016-05-27T15:09:51Zen
dc.date.available2016-05-27T15:09:51Zen
dc.date.issued2016-05-06en
dc.identifier.citationSolid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process. 2016: Eur J Pharm Biopharmen
dc.identifier.issn0939-6411en
dc.identifier.pmid27163245en
dc.identifier.doi10.1016/j.ejpb.2016.04.024en
dc.identifier.urihttp://hdl.handle.net/2436/610896en
dc.description.abstractThe aim of this study was to enhance the apparent solubility and dissolution properties of flurbiprofen through inclusion complexation with cyclodextrins. Especially, the efficacy of supercritical fluid technology as a preparative technique for the preparation of flurbiprofen-methyl-β-cyclodextrin inclusion complexes was evaluated. The complexes were prepared by supercritical carbon dioxide processing and were evaluated by solubility, differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy, practical yield, drug content estimation and in vitro dissolution studies. Computational molecular docking studies were conducted to study the possibility of molecular arrangement of inclusion complexes between flurbiprofen and methyl-β-cyclodextrin. The studies support the formation of stable molecular inclusion complexes between the drug and cyclodextrin in a 1:1 stoichiometry. In vitro dissolution studies showed that the dissolution properties of flurbiprofen were significantly enhanced by the binary mixtures prepared by supercritical carbon dioxide processing. The amount of flurbiprofen dissolved into solution alone was very low with 1.11 ± 0.09% dissolving at the end of 60 min, while the binary mixtures processed by supercritical carbon dioxide at 45 °C and 200 bar released 99.39 ± 2.34% of the drug at the end of 30 min. All the binary mixtures processed by supercritical carbon dioxide at 45 °C exhibited a drug release of more than 80% within the first 10 min irrespective of the pressure employed. The study demonstrated the single step, organic solvent-free supercritical carbon dioxide process as a promising approach for the preparation of inclusion complexes between flurbiprofen and methyl-β-cyclodextrin in solid-state.en
dc.languageENGen
dc.language.isoenen
dc.publisherElseviren
dc.relation.urlhttp://dx.doi.org/10.1016/j.ejpb.2016.04.024en
dc.rightsArchived with thanks to European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.Ven
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDissolution rateen
dc.subjectFlurbiprofenen
dc.subjectInclusion complexesen
dc.subjectMethyl–β–cyclodextrinen
dc.subjectSolubilityen
dc.subjectSupercritical fluid technologyen
dc.titleSolid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process.en
dc.typeArticleen
dc.identifier.journalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.Ven
dc.date.accepted2016-05-07en
rioxxterms.funderInternalen
rioxxterms.identifier.projectUoW270516WKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0en
rioxxterms.licenseref.startdate2018-07-01en
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