A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation.

5.00
Hdl Handle:
http://hdl.handle.net/2436/605647
Title:
A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation.
Authors:
Kaialy, Waseem ( 0000-0001-7736-4329 )
Abstract:
Pharmaceutical powders are typically insulators consisting of relatively small particles and thus they usually exhibit significant electrostatic charging behaviours. In the inhalation field, the measurement of electrostatic charge is an imperative stage during pharmaceutical formulation development. The electrostatic charge is affected by the interplay of many factors. This article reviews the factors affecting the electrostatic charging of pharmaceutical powders with a focus on dry powder inhalations. The influences of particle resistivity, size distribution, shape distribution, surface roughness, polymorphic form and hygroscopicity, as well as the effects of moisture uptake, environmental conditions, pharmaceutical processing (i.e., milling, sieving, spray drying and blending), and storage on the electrostatic charge behaviours of pharmaceuticals, with focus on inhalation powders, were reviewed. The influence of electrostatic charge on the performance of dry powder inhaler formulations in terms of drug content homogeneity, the passage of drug through the inhaler device, drug-carrier adhesion/detachment, and drug deposition on the respiratory airways were discussed. The understanding gained is crucial to improving the safety, quality, and efficiency of the pharmaceutical inhalation products.
Citation:
A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation. 2016, 503 (1-2):262-76 Int J Pharm
Publisher:
Elsevier
Journal:
International journal of pharmaceutics; Volume 503, Issues 1–2, 30 April 2016, Pages 262–276
Issue Date:
30-Apr-2016
URI:
http://hdl.handle.net/2436/605647
DOI:
10.1016/j.ijpharm.2016.01.076
PubMed ID:
26836710
Type:
Article
Language:
en
ISSN:
1873-3476
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.date.accessioned2016-04-18T09:17:38Zen
dc.date.available2016-04-18T09:17:38Zen
dc.date.issued2016-04-30en
dc.identifier.citationA review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation. 2016, 503 (1-2):262-76 Int J Pharmen
dc.identifier.issn1873-3476en
dc.identifier.pmid26836710en
dc.identifier.doi10.1016/j.ijpharm.2016.01.076en
dc.identifier.urihttp://hdl.handle.net/2436/605647en
dc.description.abstractPharmaceutical powders are typically insulators consisting of relatively small particles and thus they usually exhibit significant electrostatic charging behaviours. In the inhalation field, the measurement of electrostatic charge is an imperative stage during pharmaceutical formulation development. The electrostatic charge is affected by the interplay of many factors. This article reviews the factors affecting the electrostatic charging of pharmaceutical powders with a focus on dry powder inhalations. The influences of particle resistivity, size distribution, shape distribution, surface roughness, polymorphic form and hygroscopicity, as well as the effects of moisture uptake, environmental conditions, pharmaceutical processing (i.e., milling, sieving, spray drying and blending), and storage on the electrostatic charge behaviours of pharmaceuticals, with focus on inhalation powders, were reviewed. The influence of electrostatic charge on the performance of dry powder inhaler formulations in terms of drug content homogeneity, the passage of drug through the inhaler device, drug-carrier adhesion/detachment, and drug deposition on the respiratory airways were discussed. The understanding gained is crucial to improving the safety, quality, and efficiency of the pharmaceutical inhalation products.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to International journal of pharmaceuticsen
dc.subjectAerosolisationen
dc.subjectDry powder inhalersen
dc.subjectElectrostatic chargeen
dc.subjectPharmaceutical processingen
dc.subjectPhysicochemical propertiesen
dc.titleA review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceutics; Volume 503, Issues 1–2, 30 April 2016, Pages 262–276en
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