An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

2.50
Hdl Handle:
http://hdl.handle.net/2436/605498
Title:
An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine
Authors:
Kaialy, Waseem ( 0000-0001-7736-4329 ) ; Adebisi, Adeola O.; Hussain, Tariq; Al-Hamidi, Hiba; Nokhodchi, Ali; Conway, Barbara R.; Asare-Addo, Kofi ( 0000-0001-6824-5336 )
Abstract:
One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during the grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM. These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied. Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures was examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and/or when increasing the percentage proportion of CBZ up to 30% w:w. This study helps to provide information about the handling of these formulations and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.
Citation:
An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine 2016, 292:342 Powder Technology
Publisher:
Elsevier
Journal:
Powder Technology
Issue Date:
May-2016
URI:
http://hdl.handle.net/2436/605498
DOI:
10.1016/j.powtec.2016.02.008
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0032591016300493
Type:
Article
Language:
en
ISSN:
00325910
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorAdebisi, Adeola O.en
dc.contributor.authorHussain, Tariqen
dc.contributor.authorAl-Hamidi, Hibaen
dc.contributor.authorNokhodchi, Alien
dc.contributor.authorConway, Barbara R.en
dc.contributor.authorAsare-Addo, Kofien
dc.date.accessioned2016-04-15T15:03:35Zen
dc.date.available2016-04-15T15:03:35Zen
dc.date.issued2016-05en
dc.identifier.citationAn assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine 2016, 292:342 Powder Technologyen
dc.identifier.issn00325910en
dc.identifier.doi10.1016/j.powtec.2016.02.008en
dc.identifier.urihttp://hdl.handle.net/2436/605498en
dc.description.abstractOne of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during the grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM. These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied. Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures was examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and/or when increasing the percentage proportion of CBZ up to 30% w:w. This study helps to provide information about the handling of these formulations and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0032591016300493en
dc.rightsArchived with thanks to Powder Technologyen
dc.subjectElectrostaticsen
dc.subjectSolid dispersionsen
dc.subjectTriboelectrificationen
dc.subjectCarbamazepineen
dc.subjectD-glucosamineen
dc.subjectHCl; Polymorphismen
dc.titleAn assessment of triboelectrification effects on co-ground solid dispersions of carbamazepineen
dc.typeArticleen
dc.identifier.journalPowder Technologyen
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