Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength.

2.50
Hdl Handle:
http://hdl.handle.net/2436/605443
Title:
Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength.
Authors:
Kaialy, Waseem; Supuk, Enes; Mahdi, Mohammed H; Adebisi, Adeola O; Nep, Elijah; Conway, Barbara R; Asare-Addo, Kofi; Al-Hamidi, Hiba; Nokhodchi, Ali
Abstract:
The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1Pa, 150Pa, and 320Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5Pa, 176.2Pa and 408.3Pa for the E50LV, E4M and E10M respectively. The lower G' value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.
Citation:
Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength. 2016, 143:481-489 Colloids Surf B Biointerfaces
Publisher:
Elsevier
Journal:
Colloids and surfaces. B, Biointerfaces
Issue Date:
24-Mar-2016
URI:
http://hdl.handle.net/2436/605443
DOI:
10.1016/j.colsurfb.2016.03.066
PubMed ID:
27038913
Type:
Article
Language:
en
ISSN:
1873-4367
Appears in Collections:
FSE

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorSupuk, Enesen
dc.contributor.authorMahdi, Mohammed Hen
dc.contributor.authorAdebisi, Adeola Oen
dc.contributor.authorNep, Elijahen
dc.contributor.authorConway, Barbara Ren
dc.contributor.authorAsare-Addo, Kofien
dc.contributor.authorAl-Hamidi, Hibaen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2016-04-15T13:13:18Zen
dc.date.available2016-04-15T13:13:18Zen
dc.date.issued2016-03-24en
dc.identifier.citationDrug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength. 2016, 143:481-489 Colloids Surf B Biointerfacesen
dc.identifier.issn1873-4367en
dc.identifier.pmid27038913en
dc.identifier.doi10.1016/j.colsurfb.2016.03.066en
dc.identifier.urihttp://hdl.handle.net/2436/605443en
dc.description.abstractThe aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1Pa, 150Pa, and 320Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5Pa, 176.2Pa and 408.3Pa for the E50LV, E4M and E10M respectively. The lower G' value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.en
dc.languageENGen
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to Colloids and surfaces. B, Biointerfacesen
dc.subjectAgitation sequenceen
dc.subjectionicen
dc.subjectconcentration strengthen
dc.subjectHPMC polymeric matrix tablets triboelectrificationen
dc.subjectUSP III apparatusen
dc.subjectrheologyen
dc.titleDrug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength.en
dc.typeArticleen
dc.identifier.journalColloids and surfaces. B, Biointerfacesen
dc.identifier.urlhttp://www.sciencedirect.com/science/journal/09277765/143en

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