Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study.

2.50
Hdl Handle:
http://hdl.handle.net/2436/605291
Title:
Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study.
Authors:
Koutedakis, Yiannis; Metsios, George S; Veldhuijzen van Zanten, Jet J C S; Stavropoulos-Kalinoglou, Antonis; Vitalis, Panagiotis; Duda, Joan L; Ntoumanis, Nikos; Rouse, Peter C; Kitas, George D
Abstract:
The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA.A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases.Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity.VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA.
Citation:
Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study. 2015, 54 (12):2215-20 Rheumatology (Oxford)
Publisher:
Oxford Journals (OUP)
Journal:
Rheumatology (Oxford, England)
Issue Date:
Dec-2015
URI:
http://hdl.handle.net/2436/605291
DOI:
10.1093/rheumatology/kev035
PubMed ID:
26209790
Additional Links:
http://europepmc.org/abstract/med/26209790
Type:
Article
Language:
en
ISSN:
1462-0332
Appears in Collections:
FEHW

Full metadata record

DC FieldValue Language
dc.contributor.authorKoutedakis, Yiannisen
dc.contributor.authorMetsios, George Sen
dc.contributor.authorVeldhuijzen van Zanten, Jet J C Sen
dc.contributor.authorStavropoulos-Kalinoglou, Antonisen
dc.contributor.authorVitalis, Panagiotisen
dc.contributor.authorDuda, Joan Len
dc.contributor.authorNtoumanis, Nikosen
dc.contributor.authorRouse, Peter Cen
dc.contributor.authorKitas, George Den
dc.date.accessioned2016-04-14T15:05:54Zen
dc.date.available2016-04-14T15:05:54Zen
dc.date.issued2015-12en
dc.identifier.citationCardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study. 2015, 54 (12):2215-20 Rheumatology (Oxford)en
dc.identifier.issn1462-0332en
dc.identifier.pmid26209790en
dc.identifier.doi10.1093/rheumatology/kev035en
dc.identifier.urihttp://hdl.handle.net/2436/605291en
dc.description.abstractThe aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA.A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases.Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity.VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA.en
dc.language.isoenen
dc.publisherOxford Journals (OUP)en
dc.relation.urlhttp://europepmc.org/abstract/med/26209790en
dc.rightsArchived with thanks to Rheumatology (Oxford, England)en
dc.subjectexerciseen
dc.subjectphysical activityen
dc.subjectcardiorespiratory fitnessen
dc.subjectcardiovascular diseaseen
dc.subjectinflammationen
dc.subjectrheumatoid arthritisen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshCardiovascular Diseasesen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshExercise Testen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOxygen Consumptionen
dc.subject.meshPhysical Fitnessen
dc.subject.meshRisk Factorsen
dc.subject.meshSeverity of Illness Indexen
dc.titleCardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study.en
dc.typeArticleen
dc.identifier.journalRheumatology (Oxford, England)en

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