Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

2.50
Hdl Handle:
http://hdl.handle.net/2436/601336
Title:
Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges
Authors:
Kaialy, Waseem ( 0000-0001-7736-4329 ) ; Al Shafiee, Maen
Abstract:
The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current ‘bottom-up’ and ‘top-down’ technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.
Citation:
Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges 2016, 228:71 Advances in Colloid and Interface Science
Publisher:
Elsevier BV
Journal:
Advances in Colloid and Interface Science vol 228 pp 71-91 (ISSN: 0001-8686)
Issue Date:
Feb-2016
URI:
http://hdl.handle.net/2436/601336
DOI:
10.1016/j.cis.2015.11.010
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0001868615002183
Type:
Article
Language:
en
ISSN:
00018686
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorAl Shafiee, Maenen
dc.date.accessioned2016-03-15T10:26:30Zen
dc.date.available2016-03-15T10:26:30Zen
dc.date.issued2016-02en
dc.identifier.citationRecent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges 2016, 228:71 Advances in Colloid and Interface Scienceen
dc.identifier.issn00018686en
dc.identifier.doi10.1016/j.cis.2015.11.010en
dc.identifier.urihttp://hdl.handle.net/2436/601336en
dc.description.abstractThe advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current ‘bottom-up’ and ‘top-down’ technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.en
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0001868615002183en
dc.rightsArchived with thanks to Advances in Colloid and Interface Scienceen
dc.subjectBioavailabilityen
dc.subjectDissolution rateen
dc.subjectNanoparticle engineeringen
dc.subjectNanosizingen
dc.subjectPoorly soluble APIsen
dc.subjectSolubilityen
dc.titleRecent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challengesen
dc.typeArticleen
dc.identifier.journalAdvances in Colloid and Interface Science vol 228 pp 71-91 (ISSN: 0001-8686)en
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