The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers.

2.50
Hdl Handle:
http://hdl.handle.net/2436/576022
Title:
The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers.
Authors:
Kaialy, Waseem; Martin, Gary P; Larhrib, Hassan; Ticehurst, Martyn D; Kolosionek, Ewa; Nokhodchi, Ali
Abstract:
The aim of this work was to investigate the mechanistic evaluation of physicochemical properties of new engineered lactose on aerosolisation performance of salbutamol sulphate (SS) delivered from dry powder inhaler (DPI). Different crystallised lactose particles were obtained from binary mixtures of butanol:acetone. The sieved fractions (63-90 μm) of crystallised lactose were characterised in terms of size, shape, flowability, true density and aerosolisation performance (using multiple twin stage impinger (MSLI), Aerolizer(®) inhaler device, and salbutamol sulphate as a model drug). Compared to commercial lactose, crystallised lactose particles were less elongated, covered with fine lactose particles, and had a rougher surface morphology. The crystallised lactose powders had a considerably lower bulk and tap density and poorer flow when compared to commercial lactose. Engineered carrier with better flow showed improved drug content homogeneity, reduced amounts of drug "deposited" on the inhaler device and throat, and a smaller drug aerodynamic diameter upon inhalation. Aerodynamic diameter of salbutamol sulphate increased as lactose aerodynamic diameter decreased (linear, R(2)=0.9191) and/or as fine particle lactose content increased (linear, R(2)=0.8653). Improved drug aerosolisation performance in the case of crystallised lactose particles was attributed to lower drug-carrier adhesion forces due to a rougher surface and higher fine particle content. In conclusion, this work proved that using binary combinations of solvents in crystallisation medium is vital in modification of the physicochemical and micromeritic properties of carriers to achieve a desirable aerosolisation performance from DPI formulations. Among all lactose samples, lactose particles crystallised from pure butanol generated the highest overall DPI formulations desirability.
Citation:
The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers. 2012, 89:29-39 Colloids Surf B Biointerfaces
Publisher:
Elsevier
Journal:
Colloids and surfaces. B, Biointerfaces
Issue Date:
1-Jan-2012
URI:
http://hdl.handle.net/2436/576022
DOI:
10.1016/j.colsurfb.2011.08.019
PubMed ID:
21962946
Type:
Article
Language:
en
ISSN:
1873-4367
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorMartin, Gary Pen
dc.contributor.authorLarhrib, Hassanen
dc.contributor.authorTicehurst, Martyn Den
dc.contributor.authorKolosionek, Ewaen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-27T14:51:36Zen
dc.date.available2015-08-27T14:51:36Zen
dc.date.issued2012-01-01en
dc.identifier.citationThe influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers. 2012, 89:29-39 Colloids Surf B Biointerfacesen
dc.identifier.issn1873-4367en
dc.identifier.pmid21962946en
dc.identifier.doi10.1016/j.colsurfb.2011.08.019en
dc.identifier.urihttp://hdl.handle.net/2436/576022en
dc.description.abstractThe aim of this work was to investigate the mechanistic evaluation of physicochemical properties of new engineered lactose on aerosolisation performance of salbutamol sulphate (SS) delivered from dry powder inhaler (DPI). Different crystallised lactose particles were obtained from binary mixtures of butanol:acetone. The sieved fractions (63-90 μm) of crystallised lactose were characterised in terms of size, shape, flowability, true density and aerosolisation performance (using multiple twin stage impinger (MSLI), Aerolizer(®) inhaler device, and salbutamol sulphate as a model drug). Compared to commercial lactose, crystallised lactose particles were less elongated, covered with fine lactose particles, and had a rougher surface morphology. The crystallised lactose powders had a considerably lower bulk and tap density and poorer flow when compared to commercial lactose. Engineered carrier with better flow showed improved drug content homogeneity, reduced amounts of drug "deposited" on the inhaler device and throat, and a smaller drug aerodynamic diameter upon inhalation. Aerodynamic diameter of salbutamol sulphate increased as lactose aerodynamic diameter decreased (linear, R(2)=0.9191) and/or as fine particle lactose content increased (linear, R(2)=0.8653). Improved drug aerosolisation performance in the case of crystallised lactose particles was attributed to lower drug-carrier adhesion forces due to a rougher surface and higher fine particle content. In conclusion, this work proved that using binary combinations of solvents in crystallisation medium is vital in modification of the physicochemical and micromeritic properties of carriers to achieve a desirable aerosolisation performance from DPI formulations. Among all lactose samples, lactose particles crystallised from pure butanol generated the highest overall DPI formulations desirability.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to Colloids and surfaces. B, Biointerfacesen
dc.subjectDry powder inhaleren
dc.subjectNon-solventen
dc.subjectInhalation efficiencyen
dc.subjectLactose crystallisationen
dc.subjectMorphologyen
dc.subjectCarrieren
dc.subject.meshAlbuterolen
dc.subject.meshBronchodilator Agentsen
dc.subject.meshCrystallizationen
dc.subject.meshLactoseen
dc.subject.meshMicroscopy, Electron, Scanningen
dc.subject.meshNebulizers and Vaporizersen
dc.subject.meshParticle Sizeen
dc.subject.meshPowdersen
dc.subject.meshSurface Propertiesen
dc.titleThe influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers.en
dc.typeArticleen
dc.identifier.journalColloids and surfaces. B, Biointerfacesen

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