Engineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations.

2.50
Hdl Handle:
http://hdl.handle.net/2436/576021
Title:
Engineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations.
Authors:
Kaialy, Waseem; Nokhodchi, Ali
Abstract:
The aim of this study was to evaluate the influence of novel engineered fine mannitol particles (4.7%, w/w) on the performance of lactose-salbutamol sulphate dry powder inhaler (DPI) formulations to obtain promising aerosolisation properties. The results showed that the more elongated the fine mannitol particles, the weaker the drug-carrier adhesion, the better the drug content homogeneity, the higher the amount of drug expected to be delivered to the lower airways and the higher the total DPI formulation desirability. Linear relationships were established showing that mannitol particles with a more elongated shape generated powders with broader size distributions and that were less uniform in shape. The weaker the drug-carrier adhesion, the higher the fine particle fraction of the drug is upon aerosolisation. It is believed that more elongated fine mannitol particles reduce the number of drug-carrier and drug-drug physical contact points and increase the ability of the drug particles to travel into the lower airways. Additionally, a lower drug-carrier contact area, lower drug-carrier press-on forces and easier drug-carrier detachment are suggested in the case of formulations containing more elongated fine mannitol particles. Ternary 'drug-coarse carrier-elongated fine ternary component' DPI formulations were more favourable than both 'drug-coarse carrier' and 'drug-elongated coarse carrier' binary formulations. This study provides a comprehensive approach for formulators to overcome the undesirable properties of dry powder inhalers, as both improved aerosolisation performance and reasonable flow characteristics were obtained using only a small amount of elongated engineered fine mannitol particles.
Citation:
Engineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations. 2013, 15 (3):728-43 AAPS J
Publisher:
Springer
Journal:
The AAPS journal
Issue Date:
Jul-2013
URI:
http://hdl.handle.net/2436/576021
DOI:
10.1208/s12248-013-9476-4
PubMed ID:
23591748
Type:
Article
Language:
en
ISSN:
1550-7416
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-27T14:51:07Zen
dc.date.available2015-08-27T14:51:07Zen
dc.date.issued2013-07en
dc.identifier.citationEngineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations. 2013, 15 (3):728-43 AAPS Jen
dc.identifier.issn1550-7416en
dc.identifier.pmid23591748en
dc.identifier.doi10.1208/s12248-013-9476-4en
dc.identifier.urihttp://hdl.handle.net/2436/576021en
dc.description.abstractThe aim of this study was to evaluate the influence of novel engineered fine mannitol particles (4.7%, w/w) on the performance of lactose-salbutamol sulphate dry powder inhaler (DPI) formulations to obtain promising aerosolisation properties. The results showed that the more elongated the fine mannitol particles, the weaker the drug-carrier adhesion, the better the drug content homogeneity, the higher the amount of drug expected to be delivered to the lower airways and the higher the total DPI formulation desirability. Linear relationships were established showing that mannitol particles with a more elongated shape generated powders with broader size distributions and that were less uniform in shape. The weaker the drug-carrier adhesion, the higher the fine particle fraction of the drug is upon aerosolisation. It is believed that more elongated fine mannitol particles reduce the number of drug-carrier and drug-drug physical contact points and increase the ability of the drug particles to travel into the lower airways. Additionally, a lower drug-carrier contact area, lower drug-carrier press-on forces and easier drug-carrier detachment are suggested in the case of formulations containing more elongated fine mannitol particles. Ternary 'drug-coarse carrier-elongated fine ternary component' DPI formulations were more favourable than both 'drug-coarse carrier' and 'drug-elongated coarse carrier' binary formulations. This study provides a comprehensive approach for formulators to overcome the undesirable properties of dry powder inhalers, as both improved aerosolisation performance and reasonable flow characteristics were obtained using only a small amount of elongated engineered fine mannitol particles.en
dc.language.isoenen
dc.publisherSpringeren
dc.rightsArchived with thanks to The AAPS journalen
dc.subjectadded finesen
dc.subjectadhesive mixturesen
dc.subjectengineered fine mannitolen
dc.subjectformulation performanceen
dc.subjectternary componenten
dc.subject.meshAlbuterolen
dc.subject.meshChemical Engineeringen
dc.subject.meshChemistry, Pharmaceuticalen
dc.subject.meshDry Powder Inhalersen
dc.subject.meshLactoseen
dc.subject.meshMannitolen
dc.subject.meshParticle Sizeen
dc.subject.meshSulfatesen
dc.subject.meshX-Ray Diffractionen
dc.titleEngineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations.en
dc.typeArticleen
dc.identifier.journalThe AAPS journalen

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