2.50
Hdl Handle:
http://hdl.handle.net/2436/576020
Title:
Effect of carrier particle shape on dry powder inhaler performance.
Authors:
Kaialy, Waseem; Alhalaweh, Amjad; Velaga, Sitaram P; Nokhodchi, Ali
Abstract:
The aim of this study was to characterise the aerosolisation properties of salbutamol sulphate (SS) from dry powder inhaler (DPI) formulations containing different carrier products. The difference in the elongation ratio (ER) of the different carriers was highlighted. Different set of carriers, namely commercial mannitol (CM), commercial lactose (CL), cooling crystallised mannitol (CCM), acetone crystallised mannitol (ACM) and ethanol crystallised mannitol (ECM) were used and inspected in terms of size, shape, density, crystal form, flowability, and in vitro aerosolisation performance using Multi Stage Liquid Impinger (MSLI) and Aerolizer inhaler device. Solid-state and morphological characterization showed that CM product was in pure β-form having particles with smaller ER (CM: ER=1.62 ± 0.04) whereas ACM and ECM mannitol particles were in pure α form with higher ER (ACM: ER=4.83 ± 0.18, ECM: ER=5.89 ± 0.19). CCM product crystallised as mixtures of β-form and δ-form and showed the largest variability in terms of particle shape, size, and DPI performance. Linear relationships were established showing that carrier products with higher ER have smaller bulk density (D(b)), smaller tap density (D(t)), higher porosity (P), and poorer flow properties. In vitro aerosolisation assessments showed that the higher the ER of the carrier particles the greater the amounts of SS delivered to lower airway regions indicating enhanced DPI performance. Yet, DPI performance enhancement by increasing carrier ER reached a "limit" as increasing carrier ER from 4.83±0.18 (ACM) to 5.89±0.19 (ECM) did not significantly alter fine particle fraction (FPF) of SS. Also, carrier particles with higher ER were disadvantageous in terms of higher amounts of SS remained in inhaler device (drug loss) and deposited on throat. Linear relationship was established (r(2)=0.87) showing that the higher the carrier ER the lower the drug emission (EM) upon inhalation. Moreover, poorer flowability for carrier products with higher ER is disadvantageous in terms of DPI formulation dose metering and processing on handling scale. In conclusion, despite that using carrier particles with higher ER can considerably increase the amounts of drug delivered to lower airway regions; this enhancement is restricted to certain point. Also, other limitations should be taken into account including higher drug loss and poorer flowability.
Citation:
Effect of carrier particle shape on dry powder inhaler performance. 2011, 421 (1):12-23 Int J Pharm
Publisher:
Elsevier
Journal:
International journal of pharmaceutics
Issue Date:
12-Dec-2011
URI:
http://hdl.handle.net/2436/576020
DOI:
10.1016/j.ijpharm.2011.09.010
PubMed ID:
21945739
Type:
Article
Language:
en
ISSN:
1873-3476
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorAlhalaweh, Amjaden
dc.contributor.authorVelaga, Sitaram Pen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-27T14:49:30Zen
dc.date.available2015-08-27T14:49:30Zen
dc.date.issued2011-12-12en
dc.identifier.citationEffect of carrier particle shape on dry powder inhaler performance. 2011, 421 (1):12-23 Int J Pharmen
dc.identifier.issn1873-3476en
dc.identifier.pmid21945739en
dc.identifier.doi10.1016/j.ijpharm.2011.09.010en
dc.identifier.urihttp://hdl.handle.net/2436/576020en
dc.description.abstractThe aim of this study was to characterise the aerosolisation properties of salbutamol sulphate (SS) from dry powder inhaler (DPI) formulations containing different carrier products. The difference in the elongation ratio (ER) of the different carriers was highlighted. Different set of carriers, namely commercial mannitol (CM), commercial lactose (CL), cooling crystallised mannitol (CCM), acetone crystallised mannitol (ACM) and ethanol crystallised mannitol (ECM) were used and inspected in terms of size, shape, density, crystal form, flowability, and in vitro aerosolisation performance using Multi Stage Liquid Impinger (MSLI) and Aerolizer inhaler device. Solid-state and morphological characterization showed that CM product was in pure β-form having particles with smaller ER (CM: ER=1.62 ± 0.04) whereas ACM and ECM mannitol particles were in pure α form with higher ER (ACM: ER=4.83 ± 0.18, ECM: ER=5.89 ± 0.19). CCM product crystallised as mixtures of β-form and δ-form and showed the largest variability in terms of particle shape, size, and DPI performance. Linear relationships were established showing that carrier products with higher ER have smaller bulk density (D(b)), smaller tap density (D(t)), higher porosity (P), and poorer flow properties. In vitro aerosolisation assessments showed that the higher the ER of the carrier particles the greater the amounts of SS delivered to lower airway regions indicating enhanced DPI performance. Yet, DPI performance enhancement by increasing carrier ER reached a "limit" as increasing carrier ER from 4.83±0.18 (ACM) to 5.89±0.19 (ECM) did not significantly alter fine particle fraction (FPF) of SS. Also, carrier particles with higher ER were disadvantageous in terms of higher amounts of SS remained in inhaler device (drug loss) and deposited on throat. Linear relationship was established (r(2)=0.87) showing that the higher the carrier ER the lower the drug emission (EM) upon inhalation. Moreover, poorer flowability for carrier products with higher ER is disadvantageous in terms of DPI formulation dose metering and processing on handling scale. In conclusion, despite that using carrier particles with higher ER can considerably increase the amounts of drug delivered to lower airway regions; this enhancement is restricted to certain point. Also, other limitations should be taken into account including higher drug loss and poorer flowability.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to International journal of pharmaceuticsen
dc.subjectMannitolen
dc.subjectLactoseen
dc.subjectCarrier shapeen
dc.subjectFlow propertiesen
dc.subjectCrystal formen
dc.subjectSalbutamol sulphateen
dc.subjectUniformityen
dc.subjectAerosolisation performanceen
dc.subject.meshAlbuterolen
dc.subject.meshBronchodilator Agentsen
dc.subject.meshDrug Carriersen
dc.subject.meshDry Powder Inhalersen
dc.subject.meshLactoseen
dc.subject.meshMannitolen
dc.subject.meshParticle Sizeen
dc.subject.meshPorosityen
dc.subject.meshRheologyen
dc.titleEffect of carrier particle shape on dry powder inhaler performance.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceuticsen

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