The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient.

2.50
Hdl Handle:
http://hdl.handle.net/2436/576019
Title:
The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient.
Authors:
Kaialy, Waseem; Martin, Gary P; Ticehurst, Martyn D; Momin, Mohammed N; Nokhodchi, Ali
Abstract:
The aim of the present study was to investigate the effect of crystallising mannitol from different binary mixtures of acetone/water on the resultant physical properties and to determine the effects of any changes on in vitro aerosolisation performance, when the different mannitol crystals were used as a carrier in dry powder inhaler formulations containing salbutamol sulphate. Mannitol particles were crystallised under controlled conditions by dissolving the sugar in water and precipitating the sugar using binary mixtures of acetone/water in different percentages as anti-solvent media. For comparison purposes the physical properties and deposition behaviour of commercially available mannitol were also studied. SEM showed that all crystallised mannitol particles were more elongated than the commercial mannitol. Solid state studies revealed that commercial mannitol and mannitol crystallised using acetone in the presence of 10-25% v/v water as anti-solvent was beta-polymorphic form whereas mannitol crystallised in the presence of a small amount of water (0-7.5%) was the alpha-form. All the crystallised mannitol samples showed poor flowability. Nevertheless, the powdered crystallised mannitol and commercial samples were blended with salbutamol in the ratio 67.5:1. The aerosolisation performance of the formulations containing the engineered mannitol (evaluated using Multi Stage Liquid Impinger) was considerably better than that of the commercial mannitol formulation (the fine particle fraction was increased from 15.42% to 33.07-43.99%, for the formulations containing crystallised mannitol). Generally, carriers having a high tapped density and high fraction of fine carrier particles produced a high FPF. The improvement in the DPI performance could be attributed to the presence of elongated carrier particles with smooth surfaces since these are believed to have less adhesive forces between carrier and the drug resulting in easier detachment of the drug during the inhalation.
Citation:
The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient. 2010, 392 (1-2):178-88 Int J Pharm
Publisher:
el
Journal:
International journal of pharmaceutics
Issue Date:
15-Jun-2010
URI:
http://hdl.handle.net/2436/576019
DOI:
10.1016/j.ijpharm.2010.03.057
PubMed ID:
20363301
Type:
Article
Language:
en
ISSN:
1873-3476
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorMartin, Gary Pen
dc.contributor.authorTicehurst, Martyn Den
dc.contributor.authorMomin, Mohammed Nen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-27T14:48:26Zen
dc.date.available2015-08-27T14:48:26Zen
dc.date.issued2010-06-15en
dc.identifier.citationThe enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient. 2010, 392 (1-2):178-88 Int J Pharmen
dc.identifier.issn1873-3476en
dc.identifier.pmid20363301en
dc.identifier.doi10.1016/j.ijpharm.2010.03.057en
dc.identifier.urihttp://hdl.handle.net/2436/576019en
dc.description.abstractThe aim of the present study was to investigate the effect of crystallising mannitol from different binary mixtures of acetone/water on the resultant physical properties and to determine the effects of any changes on in vitro aerosolisation performance, when the different mannitol crystals were used as a carrier in dry powder inhaler formulations containing salbutamol sulphate. Mannitol particles were crystallised under controlled conditions by dissolving the sugar in water and precipitating the sugar using binary mixtures of acetone/water in different percentages as anti-solvent media. For comparison purposes the physical properties and deposition behaviour of commercially available mannitol were also studied. SEM showed that all crystallised mannitol particles were more elongated than the commercial mannitol. Solid state studies revealed that commercial mannitol and mannitol crystallised using acetone in the presence of 10-25% v/v water as anti-solvent was beta-polymorphic form whereas mannitol crystallised in the presence of a small amount of water (0-7.5%) was the alpha-form. All the crystallised mannitol samples showed poor flowability. Nevertheless, the powdered crystallised mannitol and commercial samples were blended with salbutamol in the ratio 67.5:1. The aerosolisation performance of the formulations containing the engineered mannitol (evaluated using Multi Stage Liquid Impinger) was considerably better than that of the commercial mannitol formulation (the fine particle fraction was increased from 15.42% to 33.07-43.99%, for the formulations containing crystallised mannitol). Generally, carriers having a high tapped density and high fraction of fine carrier particles produced a high FPF. The improvement in the DPI performance could be attributed to the presence of elongated carrier particles with smooth surfaces since these are believed to have less adhesive forces between carrier and the drug resulting in easier detachment of the drug during the inhalation.en
dc.language.isoenen
dc.publisherelen
dc.rightsArchived with thanks to International journal of pharmaceuticsen
dc.subjectDry powder inhaleren
dc.subjectMannitolen
dc.subjectMicromeriticen
dc.subjectDeposition studyen
dc.subjectCrystallisationen
dc.subjectRatio of acetone/wateren
dc.subject.meshAerosolsen
dc.subject.meshAlbuterolen
dc.subject.meshBronchodilator Agentsen
dc.subject.meshCalorimetry, Differential Scanningen
dc.subject.meshChromatography, High Pressure Liquiden
dc.subject.meshCrystallizationen
dc.subject.meshDrug Carriersen
dc.subject.meshExcipientsen
dc.subject.meshMannitolen
dc.subject.meshMicroscopy, Electron, Scanningen
dc.subject.meshNebulizers and Vaporizersen
dc.subject.meshParticle Sizeen
dc.subject.meshPowdersen
dc.subject.meshSpectroscopy, Fourier Transform Infrareden
dc.subject.meshSurface Propertiesen
dc.titleThe enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceuticsen

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