Treating mannitol in a saturated solution of mannitol: a novel approach to modify mannitol crystals for improved drug delivery to the lungs.

2.50
Hdl Handle:
http://hdl.handle.net/2436/575955
Title:
Treating mannitol in a saturated solution of mannitol: a novel approach to modify mannitol crystals for improved drug delivery to the lungs.
Authors:
Kaialy, Waseem; Nokhodchi, Ali
Abstract:
The aim of this study was to evaluate the influence of treatment of a promising dry powder aerosol carrier (mannitol) on the aerosolization performance of salbutamol sulphate (SS) using a novel approach: treating excess commercial carrier particles in a saturated solution of the same carrier. Commercial mannitol (CM) particles were treated with aqueous mannitol supersaturated solutions (20% and 25% w/v), under stirring, (300 rpm) for either 24h or 48 h. The results showed that particle treatment did not alter the polymorphic form of mannitol (β-mannitol); however, all treated mannitol particles demonstrated smoother surface topography and improved aerosolization performance compared to CM in dry powder inhalations. Unlike the concentration of mannitol solution used during treatment, the time of treatment to collect mannitol crystals was an essential key to modify the physical properties of mannitol and its effect on the aerosolization performance. In comparison to mannitol particles treated for 48 h, mannitol particles treated for 24h demonstrated larger size, more elongated-less regular shape, and smoother surfaces. No apparent relationship was obtained between in vitro aerosolisation behavior of SS with either mannitol particle size or shape descriptors. However, despite their larger size and more irregular-less uniformed shape, treated mannitol particles with smoother surfaces generated drug particles with smaller aerodynamic size and are expected to deliver higher amounts of drug to lower airways. The results demonstrated the potential of treating mannitol particles in aqueous solutions of the same material under controlled conditions to produce mannitol particles promising for dry powder inhaler systems. The results suggested that mannitol particle surface texture properties dominate over both particle size and particle shape of mannitol in terms of determining the aerosolization performance of mannitol.
Citation:
Treating mannitol in a saturated solution of mannitol: a novel approach to modify mannitol crystals for improved drug delivery to the lungs. 2013, 448 (1):58-70 Int J Pharm
Publisher:
Elsevier
Journal:
International journal of pharmaceutics
Issue Date:
1-May-2013
URI:
http://hdl.handle.net/2436/575955
DOI:
10.1016/j.ijpharm.2013.03.005
PubMed ID:
23500603
Type:
Article
Language:
en
ISSN:
1873-3476
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-25T13:59:01Zen
dc.date.available2015-08-25T13:59:01Zen
dc.date.issued2013-05-01en
dc.identifier.citationTreating mannitol in a saturated solution of mannitol: a novel approach to modify mannitol crystals for improved drug delivery to the lungs. 2013, 448 (1):58-70 Int J Pharmen
dc.identifier.issn1873-3476en
dc.identifier.pmid23500603en
dc.identifier.doi10.1016/j.ijpharm.2013.03.005en
dc.identifier.urihttp://hdl.handle.net/2436/575955en
dc.description.abstractThe aim of this study was to evaluate the influence of treatment of a promising dry powder aerosol carrier (mannitol) on the aerosolization performance of salbutamol sulphate (SS) using a novel approach: treating excess commercial carrier particles in a saturated solution of the same carrier. Commercial mannitol (CM) particles were treated with aqueous mannitol supersaturated solutions (20% and 25% w/v), under stirring, (300 rpm) for either 24h or 48 h. The results showed that particle treatment did not alter the polymorphic form of mannitol (β-mannitol); however, all treated mannitol particles demonstrated smoother surface topography and improved aerosolization performance compared to CM in dry powder inhalations. Unlike the concentration of mannitol solution used during treatment, the time of treatment to collect mannitol crystals was an essential key to modify the physical properties of mannitol and its effect on the aerosolization performance. In comparison to mannitol particles treated for 48 h, mannitol particles treated for 24h demonstrated larger size, more elongated-less regular shape, and smoother surfaces. No apparent relationship was obtained between in vitro aerosolisation behavior of SS with either mannitol particle size or shape descriptors. However, despite their larger size and more irregular-less uniformed shape, treated mannitol particles with smoother surfaces generated drug particles with smaller aerodynamic size and are expected to deliver higher amounts of drug to lower airways. The results demonstrated the potential of treating mannitol particles in aqueous solutions of the same material under controlled conditions to produce mannitol particles promising for dry powder inhaler systems. The results suggested that mannitol particle surface texture properties dominate over both particle size and particle shape of mannitol in terms of determining the aerosolization performance of mannitol.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to International journal of pharmaceuticsen
dc.subjectDry powder inhaleren
dc.subjectMannitolen
dc.subjectSurface roughnessen
dc.subjectAgglomerationen
dc.subjectAggregationen
dc.subject.meshAdministration, Inhalationen
dc.subject.meshAerosolsen
dc.subject.meshAlbuterolen
dc.subject.meshCalorimetry, Differential Scanningen
dc.subject.meshCrystallizationen
dc.subject.meshDrug Delivery Systemsen
dc.subject.meshLungen
dc.subject.meshMannitolen
dc.subject.meshMicroscopy, Atomic Forceen
dc.subject.meshMicroscopy, Electron, Scanningen
dc.subject.meshParticle Sizeen
dc.subject.meshPowdersen
dc.subject.meshSpectroscopy, Fourier Transform Infrareden
dc.titleTreating mannitol in a saturated solution of mannitol: a novel approach to modify mannitol crystals for improved drug delivery to the lungs.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceuticsen

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