Dissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhancer

2.50
Hdl Handle:
http://hdl.handle.net/2436/565050
Title:
Dissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhancer
Authors:
Nokhodchi, Ali; Al-Hamidi, Hiba; Antonijevic, Milan D.; Owusu-Ware, Samuel; Kaialy, Waseem
Abstract:
Solid dispersions are one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however, this is reliant on the selection of a suitable carrier and solvent. The present study is the mechanistic evaluation of the changes in polymorphic form of carbamazepine when the type of solvent and the concentration of d-gluconolactone (d-GL) change. The studies reported herein also explore the use of d-GL as a potential hydrophilic carrier to improve the dissolution rate of a poorly water-soluble drug, carbamazepine (CBZ), from physical mixtures and solid dispersion formulations. The effect of using different solvents in the preparation of solid dispersion formulations was also investigated. Different ratios of solid dispersions of the drug and d-GL were prepared using a conventional solvent evaporation method. Different solvents (ethanol, acetone and water) were used as a second experimental variable in the preparation of solid dispersions. Physical mixtures of CBZ and d-GL were also prepared for comparison. The results showed that the presence of d-GL can increase the dissolution rate of CBZ compared to pure CBZ. This study showed that d-GL could be used as a new carrier in solid dispersion formulations and physical mixtures. The interesting solid state behaviour of CBZ in all solid dispersions in the presence of d-GL was fully analyzed using Fourier-transform infrared (FT-IR), X-ray powder diffraction (XRPD), scanning electron microscope (SEM), hot stage microscopy (HSM) and differential scanning calorimetry (DSC). The results showed that depending on the type of solvent and concentration of d-GL used in the preparation of solid dispersions different forms of CBZ (Form I, Form III and dihydrate) can be existed in the formulations
Citation:
Dissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhancer 2015, 100:452 Chemical Engineering Research and Design
Publisher:
Elsevier
Journal:
Chemical Engineering Research and Design
Issue Date:
Aug-2015
URI:
http://hdl.handle.net/2436/565050
DOI:
10.1016/j.cherd.2015.04.018
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0263876215001227
Type:
Article
Language:
en
ISSN:
02638762
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorNokhodchi, Alien
dc.contributor.authorAl-Hamidi, Hibaen
dc.contributor.authorAntonijevic, Milan D.en
dc.contributor.authorOwusu-Ware, Samuelen
dc.contributor.authorKaialy, Waseemen
dc.date.accessioned2015-08-04T11:05:04Zen
dc.date.available2015-08-04T11:05:04Zen
dc.date.issued2015-08en
dc.identifier.citationDissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhancer 2015, 100:452 Chemical Engineering Research and Designen
dc.identifier.issn02638762en
dc.identifier.doi10.1016/j.cherd.2015.04.018en
dc.identifier.urihttp://hdl.handle.net/2436/565050en
dc.description.abstractSolid dispersions are one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however, this is reliant on the selection of a suitable carrier and solvent. The present study is the mechanistic evaluation of the changes in polymorphic form of carbamazepine when the type of solvent and the concentration of d-gluconolactone (d-GL) change. The studies reported herein also explore the use of d-GL as a potential hydrophilic carrier to improve the dissolution rate of a poorly water-soluble drug, carbamazepine (CBZ), from physical mixtures and solid dispersion formulations. The effect of using different solvents in the preparation of solid dispersion formulations was also investigated. Different ratios of solid dispersions of the drug and d-GL were prepared using a conventional solvent evaporation method. Different solvents (ethanol, acetone and water) were used as a second experimental variable in the preparation of solid dispersions. Physical mixtures of CBZ and d-GL were also prepared for comparison. The results showed that the presence of d-GL can increase the dissolution rate of CBZ compared to pure CBZ. This study showed that d-GL could be used as a new carrier in solid dispersion formulations and physical mixtures. The interesting solid state behaviour of CBZ in all solid dispersions in the presence of d-GL was fully analyzed using Fourier-transform infrared (FT-IR), X-ray powder diffraction (XRPD), scanning electron microscope (SEM), hot stage microscopy (HSM) and differential scanning calorimetry (DSC). The results showed that depending on the type of solvent and concentration of d-GL used in the preparation of solid dispersions different forms of CBZ (Form I, Form III and dihydrate) can be existed in the formulationsen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0263876215001227en
dc.rightsArchived with thanks to Chemical Engineering Research and Designen
dc.subjectSolid dispersionsen
dc.subjectCarbamazepin-gluconolactoneen
dc.subjectDissolution enhancementen
dc.subjectEutectic mixturesen
dc.subjectMechanistic solid state analysisen
dc.titleDissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhanceren
dc.typeArticleen
dc.identifier.journalChemical Engineering Research and Designen
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