Investigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant.

2.50
Hdl Handle:
http://hdl.handle.net/2436/565030
Title:
Investigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant.
Authors:
Shojaee, Saeed; Nokhodchi, Ali; Cumming, Iain; Alhalaweh, Amjad; Kaialy, Waseem
Abstract:
The objective of this study wasto investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant.The resulted showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HClfrom aged PEO matrix tablets, which was similar to fresh sample, regardless of molecular weight (MW) of PEO. However, the influence of the presence of vitamin E on the release rate of partially soluble drug, theophylline, was dependent on the MW of PEO; i.e., fast and unstable drug release was obtained in the case of low MW PEO 750 whereas stable drug release was obtained in the case of high MW PEO 303. The release of low water-soluble drug zonisamidewas stable regardless of both the presence of vitamin E and the MW of PEO. The presence of vitamin E slightly slowed the release ofzonisamide from aged PEO 303 matrices but not PEO 750 matrices. Therefore, in order to achieve a suitable controlled release profile from PEO matrices, not only the presence of vitamin E but also the solubility of drug and the MW of polyox should be considered.
Citation:
Investigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant. 2015: Curr Drug Deliv
Publisher:
Bentham Science Publishers
Journal:
Current drug delivery
Issue Date:
26-Mar-2015
URI:
http://hdl.handle.net/2436/565030
PubMed ID:
25808280
Type:
Article
Language:
en
ISSN:
1875-5704
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorShojaee, Saeeden
dc.contributor.authorNokhodchi, Alien
dc.contributor.authorCumming, Iainen
dc.contributor.authorAlhalaweh, Amjaden
dc.contributor.authorKaialy, Waseemen
dc.date.accessioned2015-08-04T10:54:17Zen
dc.date.available2015-08-04T10:54:17Zen
dc.date.issued2015-03-26en
dc.identifier.citationInvestigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant. 2015: Curr Drug Deliven
dc.identifier.issn1875-5704en
dc.identifier.pmid25808280en
dc.identifier.urihttp://hdl.handle.net/2436/565030en
dc.description.abstractThe objective of this study wasto investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant.The resulted showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HClfrom aged PEO matrix tablets, which was similar to fresh sample, regardless of molecular weight (MW) of PEO. However, the influence of the presence of vitamin E on the release rate of partially soluble drug, theophylline, was dependent on the MW of PEO; i.e., fast and unstable drug release was obtained in the case of low MW PEO 750 whereas stable drug release was obtained in the case of high MW PEO 303. The release of low water-soluble drug zonisamidewas stable regardless of both the presence of vitamin E and the MW of PEO. The presence of vitamin E slightly slowed the release ofzonisamide from aged PEO 303 matrices but not PEO 750 matrices. Therefore, in order to achieve a suitable controlled release profile from PEO matrices, not only the presence of vitamin E but also the solubility of drug and the MW of polyox should be considered.en
dc.languageENGen
dc.language.isoenen
dc.publisherBentham Science Publishersen
dc.rightsArchived with thanks to Current drug deliveryen
dc.subjectControlled releaseen
dc.subjectDrug solubilityen
dc.subjectPEO matricesen
dc.subjectStabilityen
dc.subjectVitamin Een
dc.titleInvestigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant.en
dc.typeArticleen
dc.identifier.journalCurrent drug deliveryen
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