An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices.

2.50
Hdl Handle:
http://hdl.handle.net/2436/564206
Title:
An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices.
Authors:
Shojaee, Saeed; Emami, Parastou; Mahmood, Ahmad; Rowaiye, Yemisi; Dukulay, Alusine; Kaialy, Waseem; Cumming, Iain; Nokhodchi, Ali
Abstract:
Polyethylene oxide has been researched extensively as an alternative polymer to hydroxypropyl methylcellulose (HPMC) in controlled drug delivery due to its desirable swelling properties and its availability in a number of different viscosity grades. Previous studies on HPMC have pointed out the importance of particle size on drug release, but as of yet, no studies have investigated the effect of particle size of polyethylene oxide (polyox) on drug release. The present study explored the relationship between polymer level and particle size to sustain the drug release. Tablets produced contained theophylline as their active ingredient and consisted of different polyethylene oxide particle size fractions (20-45, 45-90, 90-180 and 180-425 μm). It was shown that matrices containing smaller particle sizes of polyox produced harder tablets than when larger polyox particles were used. The release studies showed that matrices consisting of large polyox particles showed a faster release rate than matrices made from smaller particles. Molecular weight (MW) of the polymer was a key determining step in attaining sustained release, with the high MW of polyox resulting in a delayed release profile. The results showed that the effect of particle size on drug release was more detrimental when a low concentration of polyox was used. This indicates that care must be taken when low levels of polyox with different particle size fractions are used. More robust formulations could be obtained when the concentration of polyox is high. Differential scanning calorimetry (DSC) traces showed that particle size had no major effect on the thermal behaviour of polyox particles.
Citation:
An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices. 2015: AAPS PharmSciTech
Publisher:
Springer
Journal:
AAPS PharmSciTech
Issue Date:
14-Mar-2015
URI:
http://hdl.handle.net/2436/564206
DOI:
10.1208/s12249-015-0295-z
PubMed ID:
25771738
Type:
Article
Language:
en
ISSN:
1530-9932
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorShojaee, Saeeden
dc.contributor.authorEmami, Parastouen
dc.contributor.authorMahmood, Ahmaden
dc.contributor.authorRowaiye, Yemisien
dc.contributor.authorDukulay, Alusineen
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorCumming, Iainen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-03T14:22:51Zen
dc.date.available2015-08-03T14:22:51Zen
dc.date.issued2015-03-14en
dc.identifier.citationAn Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices. 2015: AAPS PharmSciTechen
dc.identifier.issn1530-9932en
dc.identifier.pmid25771738en
dc.identifier.doi10.1208/s12249-015-0295-zen
dc.identifier.urihttp://hdl.handle.net/2436/564206en
dc.description.abstractPolyethylene oxide has been researched extensively as an alternative polymer to hydroxypropyl methylcellulose (HPMC) in controlled drug delivery due to its desirable swelling properties and its availability in a number of different viscosity grades. Previous studies on HPMC have pointed out the importance of particle size on drug release, but as of yet, no studies have investigated the effect of particle size of polyethylene oxide (polyox) on drug release. The present study explored the relationship between polymer level and particle size to sustain the drug release. Tablets produced contained theophylline as their active ingredient and consisted of different polyethylene oxide particle size fractions (20-45, 45-90, 90-180 and 180-425 μm). It was shown that matrices containing smaller particle sizes of polyox produced harder tablets than when larger polyox particles were used. The release studies showed that matrices consisting of large polyox particles showed a faster release rate than matrices made from smaller particles. Molecular weight (MW) of the polymer was a key determining step in attaining sustained release, with the high MW of polyox resulting in a delayed release profile. The results showed that the effect of particle size on drug release was more detrimental when a low concentration of polyox was used. This indicates that care must be taken when low levels of polyox with different particle size fractions are used. More robust formulations could be obtained when the concentration of polyox is high. Differential scanning calorimetry (DSC) traces showed that particle size had no major effect on the thermal behaviour of polyox particles.en
dc.languageENGen
dc.language.isoenen
dc.publisherSpringeren
dc.rightsArchived with thanks to AAPS PharmSciTechen
dc.subjectDSC tracesen
dc.subjectparticle sizeen
dc.subjectpolyoxen
dc.subjectsustained releaseen
dc.subjecttheophyllineen
dc.titleAn Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices.en
dc.typeArticleen
dc.identifier.journalAAPS PharmSciTechen
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