Dry powder inhalers: physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol.

2.50
Hdl Handle:
http://hdl.handle.net/2436/564204
Title:
Dry powder inhalers: physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol.
Authors:
Kaialy, Waseem; Nokhodchi, Ali
Abstract:
The purpose of this work was to evaluate the physicochemical and inhalation characteristics of different size fractions of a promising carrier, i.e., freeze-dried mannitol (FDM). FDM was prepared and sieved into four size fractions. FDMs were then characterized in terms of micromeritic, solid-state and bulk properties. Dry powder inhaler (DPI) formulations were prepared using salbutamol sulphate (SS) and then evaluated in terms of drug content homogeneity and in vitro aerosolization performance. The results showed that the crystalline state of mannitol was maintained following freeze-drying for all size fractions of FDM. All FDM particles showed elongated morphology and contained mixtures of α-, β- and δ-mannitol. In comparison to small FDM particles, FDMs with larger particle sizes demonstrated narrower size distributions, higher bulk and tap densities, lower porosities and better flowability. Regardless of particle size, all FDMs generated a significantly higher (2.2-2.9-fold increase) fine particle fraction (FPF, 37.5 ± 0.9%-48.6 ± 2.8%) of SS in comparison to commercial mannitol. The FPFs of SS were related to the shape descriptors of FDM particles; however, FPFs did not prove quantitative apparent relationships with either particle size or powder bulk descriptors. Large FDM particles were more favourable than smaller particles because they produced DPI formulations with better flowability, better drug content homogeneity, lower amounts of the drug depositing on the throat and contained lower fine-particle-mannitol. Optimized stable DPI formulations with superior physicochemical and pharmaceutical properties can be achieved using larger particles of freeze-dried mannitol (FDM).
Citation:
Dry powder inhalers: physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol. 2015, 68:56-67 Eur J Pharm Sci
Publisher:
Elsevier
Journal:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Issue Date:
20-Feb-2015
URI:
http://hdl.handle.net/2436/564204
DOI:
10.1016/j.ejps.2014.12.005
PubMed ID:
25497318
Type:
Article
Language:
en
ISSN:
1879-0720
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-03T14:13:54Zen
dc.date.available2015-08-03T14:13:54Zen
dc.date.issued2015-02-20en
dc.identifier.citationDry powder inhalers: physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol. 2015, 68:56-67 Eur J Pharm Scien
dc.identifier.issn1879-0720en
dc.identifier.pmid25497318en
dc.identifier.doi10.1016/j.ejps.2014.12.005en
dc.identifier.urihttp://hdl.handle.net/2436/564204en
dc.description.abstractThe purpose of this work was to evaluate the physicochemical and inhalation characteristics of different size fractions of a promising carrier, i.e., freeze-dried mannitol (FDM). FDM was prepared and sieved into four size fractions. FDMs were then characterized in terms of micromeritic, solid-state and bulk properties. Dry powder inhaler (DPI) formulations were prepared using salbutamol sulphate (SS) and then evaluated in terms of drug content homogeneity and in vitro aerosolization performance. The results showed that the crystalline state of mannitol was maintained following freeze-drying for all size fractions of FDM. All FDM particles showed elongated morphology and contained mixtures of α-, β- and δ-mannitol. In comparison to small FDM particles, FDMs with larger particle sizes demonstrated narrower size distributions, higher bulk and tap densities, lower porosities and better flowability. Regardless of particle size, all FDMs generated a significantly higher (2.2-2.9-fold increase) fine particle fraction (FPF, 37.5 ± 0.9%-48.6 ± 2.8%) of SS in comparison to commercial mannitol. The FPFs of SS were related to the shape descriptors of FDM particles; however, FPFs did not prove quantitative apparent relationships with either particle size or powder bulk descriptors. Large FDM particles were more favourable than smaller particles because they produced DPI formulations with better flowability, better drug content homogeneity, lower amounts of the drug depositing on the throat and contained lower fine-particle-mannitol. Optimized stable DPI formulations with superior physicochemical and pharmaceutical properties can be achieved using larger particles of freeze-dried mannitol (FDM).en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciencesen
dc.subjectDry powder inhaleren
dc.subjectFine particle fractionen
dc.subjectFreeze-dried mannitolen
dc.subjectHomogeneityen
dc.subjectOverall desirabilityen
dc.subjectParticle sizeen
dc.titleDry powder inhalers: physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol.en
dc.typeArticleen
dc.identifier.journalEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciencesen

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