Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.

2.50
Hdl Handle:
http://hdl.handle.net/2436/563634
Title:
Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.
Authors:
Kaialy, Waseem; Maniruzzaman, Mohammad; Shojaee, Saeed; Nokhodchi, Ali
Abstract:
The purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of xylitol. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic polymer additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) at a range of concentrations. The crystallization process did not influence the stable polymorphic form or true density of xylitol. However, botryoidal-shaped crystallized xylitols demonstrated different particle morphologies and lower powder bulk and tap densities in comparison to subangular-shaped commercial xylitol. Xylitol crystallized without additive and xylitol crystallized in the presence of PVP or PVA demonstrated significant improvement in hardness of directly compressed tablets; however, such improvement was observed to lesser extent for xylitol crystallized in the presence of PEG. Crystallized xylitols produced enhanced dissolution profiles for indomethacin in comparison to original xylitol. The influence of additive concentration on tablet hardness was dependent on the type of additive, whereas an increased concentration of all additives provided an improvement in the dissolution behavior of indomethacin. Antisolvent crystallization using judiciously selected type and concentration of additive can be a potential approach to prepare xylitol powders with promising physicomechanical and pharmaceutical properties.
Citation:
Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance. 2014, 477 (1-2):282-93 Int J Pharm
Publisher:
Elsevier
Journal:
International journal of pharmaceutics
Issue Date:
30-Dec-2014
URI:
http://hdl.handle.net/2436/563634
DOI:
10.1016/j.ijpharm.2014.10.015
PubMed ID:
25447824
Type:
Article
Language:
en
ISSN:
1873-3476
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorManiruzzaman, Mohammaden
dc.contributor.authorShojaee, Saeeden
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-03T12:04:57Zen
dc.date.available2015-08-03T12:04:57Zen
dc.date.issued2014-12-30en
dc.identifier.citationAntisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance. 2014, 477 (1-2):282-93 Int J Pharmen
dc.identifier.issn1873-3476en
dc.identifier.pmid25447824en
dc.identifier.doi10.1016/j.ijpharm.2014.10.015en
dc.identifier.urihttp://hdl.handle.net/2436/563634en
dc.description.abstractThe purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of xylitol. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic polymer additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) at a range of concentrations. The crystallization process did not influence the stable polymorphic form or true density of xylitol. However, botryoidal-shaped crystallized xylitols demonstrated different particle morphologies and lower powder bulk and tap densities in comparison to subangular-shaped commercial xylitol. Xylitol crystallized without additive and xylitol crystallized in the presence of PVP or PVA demonstrated significant improvement in hardness of directly compressed tablets; however, such improvement was observed to lesser extent for xylitol crystallized in the presence of PEG. Crystallized xylitols produced enhanced dissolution profiles for indomethacin in comparison to original xylitol. The influence of additive concentration on tablet hardness was dependent on the type of additive, whereas an increased concentration of all additives provided an improvement in the dissolution behavior of indomethacin. Antisolvent crystallization using judiciously selected type and concentration of additive can be a potential approach to prepare xylitol powders with promising physicomechanical and pharmaceutical properties.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to International journal of pharmaceuticsen
dc.subjectAdditivesen
dc.subjectCrystallizationen
dc.subjectEngineered xylitolen
dc.subjectIndomethacinen
dc.subjectTabletingen
dc.titleAntisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.en
dc.typeArticleen
dc.identifier.journalInternational journal of pharmaceuticsen
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