Comparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type.

5.00
Hdl Handle:
http://hdl.handle.net/2436/563014
Title:
Comparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type.
Authors:
Shojaee, Saeed; Kaialy, Waseem; Cumming, Kenneth Iain; Nokhodchi, Ali
Abstract:
Abstract Polyethylene oxide (PEO) undergoes structural adjustments caused by elevated temperatures, which results in loss of its stability within direct compression tablets. The aim of this study was to evaluate the influence of filler solubility on the drug delivery process of matrix tablets containing drugs with different water-solubility properties and stored at elevated temperature. The results demonstrated that in the case of propranolol HCl (highly water-soluble) tablet matrices, soluble lactose promoted drug release, whereas, a stable release of drug was observed with insoluble DCP. A drug release pattern similar to the propranolol HCl formulation containing DCP was obtained for hydrophilic matrix tablets containing either lactose or DCP for the less water-soluble drug, zonisamide. In the case of the partially water-soluble drug, theophylline, formulated with lower molecular weight PEO 750, drug release increased considerably in the presence of both fillers with increasing storage time, however a stable release rate (similar to fresh samples) was observed in the case of higher molecular weight PEO 303 tablet matrices containing theophylline with either lactose or DCP. The hydration properties (e.g. solubility) of the diluents had a considerable effect on drug release behavior from various model matrices; this effect was dependent on both molecular weight of PEO and solubility of drug.
Citation:
Comparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type. 2014:1-7 Pharm Dev Technol
Publisher:
Informa healthcare
Journal:
Pharmaceutical development and technology
Issue Date:
20-Nov-2014
URI:
http://hdl.handle.net/2436/563014
DOI:
10.3109/10837450.2014.982823
PubMed ID:
25410967
Type:
Article
Language:
en
ISSN:
1097-9867
Appears in Collections:
Pharmacy and Natural Products Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorShojaee, Saeeden
dc.contributor.authorKaialy, Waseemen
dc.contributor.authorCumming, Kenneth Iainen
dc.contributor.authorNokhodchi, Alien
dc.date.accessioned2015-08-03T11:19:19Zen
dc.date.available2015-08-03T11:19:19Zen
dc.date.issued2014-11-20en
dc.identifier.citationComparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type. 2014:1-7 Pharm Dev Technolen
dc.identifier.issn1097-9867en
dc.identifier.pmid25410967en
dc.identifier.doi10.3109/10837450.2014.982823en
dc.identifier.urihttp://hdl.handle.net/2436/563014en
dc.description.abstractAbstract Polyethylene oxide (PEO) undergoes structural adjustments caused by elevated temperatures, which results in loss of its stability within direct compression tablets. The aim of this study was to evaluate the influence of filler solubility on the drug delivery process of matrix tablets containing drugs with different water-solubility properties and stored at elevated temperature. The results demonstrated that in the case of propranolol HCl (highly water-soluble) tablet matrices, soluble lactose promoted drug release, whereas, a stable release of drug was observed with insoluble DCP. A drug release pattern similar to the propranolol HCl formulation containing DCP was obtained for hydrophilic matrix tablets containing either lactose or DCP for the less water-soluble drug, zonisamide. In the case of the partially water-soluble drug, theophylline, formulated with lower molecular weight PEO 750, drug release increased considerably in the presence of both fillers with increasing storage time, however a stable release rate (similar to fresh samples) was observed in the case of higher molecular weight PEO 303 tablet matrices containing theophylline with either lactose or DCP. The hydration properties (e.g. solubility) of the diluents had a considerable effect on drug release behavior from various model matrices; this effect was dependent on both molecular weight of PEO and solubility of drug.en
dc.languageENGen
dc.language.isoenen
dc.publisherInforma healthcareen
dc.rightsArchived with thanks to Pharmaceutical development and technologyen
dc.subjectCalcium phosphate dihydrate dibasicen
dc.subjectlactoseen
dc.subjectpropranolol HClen
dc.subjectsustained releaseen
dc.subjecttheophyllineen
dc.subjectzonisamaideen
dc.titleComparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type.en
dc.typeArticleen
dc.identifier.journalPharmaceutical development and technologyen

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