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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/40235
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Title: Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis.
Authors: Panoulas, Vasileios F.
Douglas, Karen M. J.
Milionis, Haralampos J.
Stavropoulos-Kalinoglou, Antonios
Nightingale, Peter
Kita, Marina D.
Tselios, Andreas L.
Metsios, Giorgos S.
Elisaf, Moses S.
Kitas, George D.
Citation: Rheumatology, 46 (9): 1477-82
Publisher: Oxford University Press
Journal: Rheumatology
Issue Date: 2007
URI: http://hdl.handle.net/2436/40235
DOI: 10.1093/rheumatology/kem169
PubMed ID: 17704521
Additional Links: http://rheumatology.oxfordjournals.org/cgi/content/full/46/9/1477
Abstract: OBJECTIVES: Rheumatoid arthritis (RA) associates with excessive cardiovascular morbidity and mortality. Hypertension (HT) contributes significantly to the development of cardiovascular disease (CVD). Little is known about the factors that influence blood pressure (BP) in patients with RA. In this study, we assessed the prevalence of HT in a secondary care cohort of RA patients, and aimed to identify factors associated with its presence and inadequate control. METHODS: A total of 400 consecutive RA patients were studied. HT was defined as systolic BP >/=140 mmHg and/or diastolic BP >/=90 mmHg or current use of antihypertensive drugs. The association of HT with several demographic and RA-related factors, comorbidities and drugs was evaluated using logistic regression. RESULTS: HT was present in 282 (70.5%) patients. Of those, 171 (60.6%) received anti-hypertensive therapy, but 111 (39.4%) remained undiagnosed. Of those treated, only 37/171 (21.8%) were optimally controlled. Multivariable logistic regression revealed age (OR = 1.054, CI: 1.02 to 1.07, P = 0.001), body mass index [BMI (OR = 1.06, CI: 1.003-1.121, P = 0.038)] and prednisolone use (OR = 2.39, CI: 1.02-5.6, P = 0.045) to be independently associated with the presence of HT. BMI (OR = 1.11, CI: 1.02-1.21, P = 0.002) and the presence of CVD (OR = 4.01, CI: 1.27-12.69, P = 0.018) associated with uncontrolled HT. CONCLUSIONS: HT is highly prevalent in RA, under-diagnosed particularly in the young, and under-treated particularly in old RA patients with CVD. RA patients receiving steroids should be specifically targeted for screening and treatment; those with any cardiovascular comorbidity may require particularly aggressive monitoring and treatment strategies.
Type: Article
Language: en
Description: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version in Rheumatology 2007 46(9), 1477-1482, is available online at the links given above.
Keywords: Hypertension
Rheumatoid Arthritis
Prevalence
Cardiovascular
Control
MeSH: Age Factors
Aged
Antihypertensive Agents
Antirheumatic Agents
Arthritis, Rheumatoid
Cross-Sectional Studies
England
Female
Humans
Hypertension
Male
Middle Aged
Prevalence
Risk Factors
Severity of Illness Index
ISSN: 1462-0324
Appears in Collections: Sport, Exercise and Health Research Group

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