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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: The role of obesity and smoking

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/39979
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Title: Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: The role of obesity and smoking
Authors: Panoulas, Vasileios F.
Stavropoulos-Kalinoglou, Antonios
Metsios, Giorgos S.
Smith, Jacqueline P.
Milionis, Haralampos J.
Douglas, Karen M. J.
Nightingale, Peter
Kitas, George D.
Citation: Atherosclerosis, [IN PRESS]
Publisher: Elsevier Ltd.
Journal: Atherosclerosis
Issue Date: 2008
URI: http://hdl.handle.net/2436/39979
DOI: 10.1016/j.atherosclerosis.2008.08.036
Additional Links: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T12-4TCR1V1-5&_user=1644469&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000054077&_version=1&_urlVersion=0&_userid=1644469&md5=f3e48d9e6fceba0191df20d05ba695b6
Abstract: Abstract Background Cardiovascular morbidity and mortality are increased in rheumatoid arthritis (RA). Interleukin-6 (IL-6) is high in RA and, together with smoking and obesity, an important contributor to the development of cardiovascular disease (CVD). The present study examined the potential association of IL-6-174 G/C polymorphism, together with obesity and smoking, with the presence of CVD in RA patients. Methods and results DNA samples were collected from 383 RA patients (who also had extensive clinical and laboratory evaluations). IL-6-174 G/C was identified using real time PCR and melting curve analysis. Serum IL-6 levels were measured in a subgroup of 135 RA patients to examine the functionality of the polymorphism. Carriers of the IL6-174C-allele demonstrated increased prevalence of CVD (26.2% vs. 17.0%, p = 0.041). There was a significant association with CVD, even after adjustment for traditional CVD risk factors (OR = 1.92, 95%CI: 1.03 to 3.58, p = 0.041). IL-6 levels were significantly increased in C-allele carriers [14.02 (3.21–38.81) vs. 4.48 (2.25–16.5), p = 0.028]. No significant interactions were observed between adiposity and IL6-174G/C genotypes. There was only a trend for an interaction between ever smoking and IL6 C-allele carriers on CVD. Conclusion The IL-6-174C-allele may associate with CVD in RA patients and possibly exerts its effect via increased inflammation. This finding, if confirmed in future studies, may be used as a part of a genetic screening tool for RA patients at high CVD risk.
Type: Article
Language: en
Keywords: Rheumatoid Arthritis
Cardiovascular Disease
Interleukin 6 gene
IL6-174G/C polymorphism
Smoking
Obesity
Arthritis, Rheumatoid
ISSN: 00219150
Appears in Collections: Sport, Exercise and Health Research Group

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