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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/39977
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Title: Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function.
Authors: Flouris, Andreas D.
Metsios, Giorgos S.
Jamurtas, Athanasios Z.
Koutedakis, Yiannis
Citation: American Journal of Physiology, 294(2): E456-462
Publisher: American Physiological Society
Journal: American Journal of Physiology
Issue Date: 2008
URI: http://hdl.handle.net/2436/39977
DOI: 10.1152/ajpendo.00699.2007
PubMed ID: 18073318
Additional Links: http://ajpendo.physiology.org/cgi/content/abstract/294/2/E456
Abstract: Experimental evidence for the physiological effects of secondhand smoke (SHS) is limited, although it affects millions of people globally and its prevalence is increasing, despite currently adopted antismoking measures. Also, scarce evidence suggests that the effects of SHS may be more pronounced in men. We conducted a randomized single-blind crossover study to investigate the sex-specific SHS effects in a controlled simulated bar/restaurant environment on gonadal and thyroid hormones, inflammatory cytokines, and vascular function. Twenty-eight (women = 14) nonsmoking adults underwent a 1-h exposure to moderate SHS and a 1-h control trial. Serum and urine cotinine, gonadal and thyroid hormones, inflammatory cytokines, heart rate, and arterial blood pressure were assessed before exposure and immediately after in both trials. Results showed that testosterone (P = 0.019) and progesterone (P < 0.001) in men and 17beta-estradiol (P = 0.001) and progesterone (P < 0.001) in women were significantly decreased after SHS. In men, SHS was accompanied by increased free thyroxine (P < 0.001), triiodothyronine (P = 0.020), and decreased the triiodothyronine-to-free thyroxine ratio (P = 0.033). In women, significant SHS-induced change was observed only in free thyroxine (P = 0.010), with considerable sex variation in free thyroxine and triiodothyronine and a decrease in luteinizing hormone (P = 0.026) and follicle-stimulating hormone (P < 0.001). After SHS, IL-1beta (P = 0.001) and systolic blood pressure (P = 0.040) were increased in men but not women. We concluded that a 1-h SHS exposure at bar/restaurant levels is accompanied by decrements in gonadal hormones in both sexes and marked increases in thyroid hormone secretion, IL-1beta production, and systolic blood pressure in men.
Type: Article
Language: en
Keywords: Environmental Tobacco Smoke
Estrogen
Cytokines
Cigarette smoking
MeSH: Adult
Blood Pressure
Cardiovascular System
Cotinine
Cross-Over Studies
Estradiol
Female
Follicle Stimulating Hormone
Heart Rate
Humans
Immunity
Inflammation Mediators
Interleukin-1beta
Interleukin-6
Luteinizing Hormone
Male
Regression Analysis
Sex Characteristics
Single-Blind Method
Testosterone
Thyroid Hormones
Tobacco Smoke Pollution
Tumor Necrosis Factor-alpha
ISSN: 0193-1849
Appears in Collections: Sport, Exercise and Health Research Group

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