2.50
Hdl Handle:
http://hdl.handle.net/2436/35472
Title:
Rheumatoid Cachexia: causes, significance and possible interventions
Authors:
Metsios, Giorgos S.; Stavropoulos-Kalinoglou, Antonios; Koutedakis, Yiannis; Kitas, George D.
Abstract:
Rheumatoid arthritis is a chronic autoimmune disease characterised by joint pain and stiffness but also systemic mutli-organ involvement. Several features are due to excessive production of inflammatory cytokines, particularly tumour necrosis factor alpha, interleukin-1 and interleukin-6. These are implicated in both local synovial inflammation, which causes joint destruction, but also systemic inflammation, which can cause loss of body cell mass, amongst other phenomena. Body cell mass breakdown in rheumatoid arthritis leads to the classical, but largely ignored, metabolic abnormality known as rheumatoid cachexia. Cachexia is a very strong predictor of adverse functional outcome and death in many disease states. In this review we highlight the mechanisms linked with rheumatoid cachexia and discuss possible interventions that may limit this in patients with rheumatoid arthritis.
Citation:
Hospital Chronicles, 1(1): 20-26
Publisher:
Scientific Society of Evangelismos Hospital
Journal:
Hospital Chronicles
Issue Date:
2006
URI:
http://hdl.handle.net/2436/35472
Additional Links:
http://www.sseh.gr/Journal/viewdetails.php?Year=2006&volume=1&Issue=1&colname=chronicles
Type:
Article
Language:
en
Appears in Collections:
Sport, Exercise and Health Research Group; Exercise and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorMetsios, Giorgos S.-
dc.contributor.authorStavropoulos-Kalinoglou, Antonios-
dc.contributor.authorKoutedakis, Yiannis-
dc.contributor.authorKitas, George D.-
dc.date.accessioned2008-08-14T08:18:02Z-
dc.date.available2008-08-14T08:18:02Z-
dc.date.issued2006-
dc.identifier.citationHospital Chronicles, 1(1): 20-26en
dc.identifier.urihttp://hdl.handle.net/2436/35472-
dc.description.abstractRheumatoid arthritis is a chronic autoimmune disease characterised by joint pain and stiffness but also systemic mutli-organ involvement. Several features are due to excessive production of inflammatory cytokines, particularly tumour necrosis factor alpha, interleukin-1 and interleukin-6. These are implicated in both local synovial inflammation, which causes joint destruction, but also systemic inflammation, which can cause loss of body cell mass, amongst other phenomena. Body cell mass breakdown in rheumatoid arthritis leads to the classical, but largely ignored, metabolic abnormality known as rheumatoid cachexia. Cachexia is a very strong predictor of adverse functional outcome and death in many disease states. In this review we highlight the mechanisms linked with rheumatoid cachexia and discuss possible interventions that may limit this in patients with rheumatoid arthritis.en
dc.language.isoenen
dc.publisherScientific Society of Evangelismos Hospitalen
dc.relation.urlhttp://www.sseh.gr/Journal/viewdetails.php?Year=2006&volume=1&Issue=1&colname=chroniclesen
dc.subjectRheumatoid Arthritisen
dc.subjectCachexiaen
dc.subjectLean body massen
dc.subjectResting energy expenditureen
dc.subjectCytokinesen
dc.subjectPhysical exerciseen
dc.subjectArthritis, Rheumatoid-
dc.titleRheumatoid Cachexia: causes, significance and possible interventionsen
dc.typeArticleen
dc.identifier.journalHospital Chroniclesen
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