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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Rheumatoid Cachexia: causes, significance and possible interventions

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/35472
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Title: Rheumatoid Cachexia: causes, significance and possible interventions
Authors: Metsios, Giorgos S.
Stavropoulos-Kalinoglou, Antonios
Koutedakis, Yiannis
Kitas, George D.
Citation: Hospital Chronicles, 1(1): 20-26
Publisher: Scientific Society of Evangelismos Hospital
Journal: Hospital Chronicles
Issue Date: 2006
URI: http://hdl.handle.net/2436/35472
Additional Links: http://www.sseh.gr/Journal/viewdetails.php?Year=2006&volume=1&Issue=1&colname=chronicles
Abstract: Rheumatoid arthritis is a chronic autoimmune disease characterised by joint pain and stiffness but also systemic mutli-organ involvement. Several features are due to excessive production of inflammatory cytokines, particularly tumour necrosis factor alpha, interleukin-1 and interleukin-6. These are implicated in both local synovial inflammation, which causes joint destruction, but also systemic inflammation, which can cause loss of body cell mass, amongst other phenomena. Body cell mass breakdown in rheumatoid arthritis leads to the classical, but largely ignored, metabolic abnormality known as rheumatoid cachexia. Cachexia is a very strong predictor of adverse functional outcome and death in many disease states. In this review we highlight the mechanisms linked with rheumatoid cachexia and discuss possible interventions that may limit this in patients with rheumatoid arthritis.
Type: Article
Language: en
Keywords: Rheumatoid Arthritis
Cachexia
Lean body mass
Resting energy expenditure
Cytokines
Physical exercise
Arthritis, Rheumatoid
Appears in Collections: Sport, Exercise and Health Research Group
Exercise and Health

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