Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study

2.50
Hdl Handle:
http://hdl.handle.net/2436/35454
Title:
Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study
Authors:
Stavropoulos-Kalinoglou, Antonios; Metsios, Giorgos S.; Panoulas, Vasileios F.; Douglas, Karen M. J.; Nevill, Alan M.; Jamurtas, Athanasios Z.; Kita, Marina D.; Koutedakis, Yiannis; Kitas, George D.
Abstract:
INTRODUCTION: Rheumatoid arthritis (RA) is associated with altered metabolism leading to muscle wasting. In the general population, cigarette smoking is known to affect body composition by reducing fat and inhibiting muscle synthesis. Even though smoking has been implicated in the pathophysiology and progression of RA, its possible effects on body composition of such patients have not been studied. This cross-sectional study aimed to identify potential associations of smoking with body weight and composition of RA patients. METHODS: A total of 392 patients (290 females) with RA were assessed for body mass index (BMI), body fat (BF), fat-free mass (FFM), and waist circumference. Erythrocyte sedimentation rate, C-reactive protein, Disease Activity Score-28, and Health Assessment Questionnaire score were used to assess disease activity and severity. Smoking habit (current smoker, ex-smoker, or never-smoker) and intensity (pack-years) were also noted. RESULTS: Current smokers had a significantly lower BMI compared with ex-smokers (mean difference: male -2.6, 95% confidence interval [CI]: -3.5 to -1.7; female: -2.6, 95% CI: -4.8 to -0.5) and never-smokers (mean difference: male -1.8, 95% CI: -3 to -0.6; female: -1.4, 95% CI: -2.4 to -0.4). Similarly, the BF of current smokers was lower compared with that of ex-smokers (mean difference: male: -4.3, 95% CI: -7.5 to -1.2; female: -3.4, 95% CI: -6.4 to -0.4) and never-smokers (mean difference: male: -3.3, 95% CI: -6.3 to -0.4; female: -2.1, 95% CI: -4 to -0.2). FFM did not differ between groups. Finally, current smokers had a significantly smaller waist circumference compared with ex-smokers only (mean difference: male: -6.2, 95% CI: -10.4 to -1.9; female: -7.8, 95% CI: -13.5 to -2.1). Following adjustments for age, disease duration, and HAQ score, smoking remained a significant predictor for BMI (P < 0.001), BF (P < 0.05), and waist circumference (P < 0.05). Pack-years were inversely correlated with BF (r = -0.46; P < 0.001), and heavy smokers exhibited a significantly lower FFM (P < 0.05) compared with all other participants. CONCLUSION: Within the limitations of a cross-sectional study, it appears that cigarette smoking associates with reduced BMI and BF in patients with RA and heavy smoking associates with lower muscle mass. Smoking cessation appears to associate with increased BMI, BF, and waist circumference in these patients. These results should be confirmed in prospective studies. Given the numerous adverse effects of smoking on general health and RA, patients should be actively advised against it. However, smoking cessation regimes in RA may need to include more general lifestyle counselling, particularly about weight control.
Citation:
Arthritis Research & Therapy, 10 (3): R59
Publisher:
BioMed Central
Journal:
Arthritis Research & Therapy
Issue Date:
2008
URI:
http://hdl.handle.net/2436/35454
DOI:
10.1186/ar2429
PubMed ID:
18492239
Additional Links:
http://arthritis-research.com/content/10/3/R59
Type:
Article
Language:
en
ISSN:
1478-6362
Appears in Collections:
Sport, Exercise and Health Research Group; Exercise and Health; Learning and Teaching in Sport, Exercise and Performance

Full metadata record

DC FieldValue Language
dc.contributor.authorStavropoulos-Kalinoglou, Antonios-
dc.contributor.authorMetsios, Giorgos S.-
dc.contributor.authorPanoulas, Vasileios F.-
dc.contributor.authorDouglas, Karen M. J.-
dc.contributor.authorNevill, Alan M.-
dc.contributor.authorJamurtas, Athanasios Z.-
dc.contributor.authorKita, Marina D.-
dc.contributor.authorKoutedakis, Yiannis-
dc.contributor.authorKitas, George D.-
dc.date.accessioned2008-08-14T08:27:45Z-
dc.date.available2008-08-14T08:27:45Z-
dc.date.issued2008-
dc.identifier.citationArthritis Research & Therapy, 10 (3): R59en
dc.identifier.issn1478-6362-
dc.identifier.pmid18492239-
dc.identifier.doi10.1186/ar2429-
dc.identifier.urihttp://hdl.handle.net/2436/35454-
dc.description.abstractINTRODUCTION: Rheumatoid arthritis (RA) is associated with altered metabolism leading to muscle wasting. In the general population, cigarette smoking is known to affect body composition by reducing fat and inhibiting muscle synthesis. Even though smoking has been implicated in the pathophysiology and progression of RA, its possible effects on body composition of such patients have not been studied. This cross-sectional study aimed to identify potential associations of smoking with body weight and composition of RA patients. METHODS: A total of 392 patients (290 females) with RA were assessed for body mass index (BMI), body fat (BF), fat-free mass (FFM), and waist circumference. Erythrocyte sedimentation rate, C-reactive protein, Disease Activity Score-28, and Health Assessment Questionnaire score were used to assess disease activity and severity. Smoking habit (current smoker, ex-smoker, or never-smoker) and intensity (pack-years) were also noted. RESULTS: Current smokers had a significantly lower BMI compared with ex-smokers (mean difference: male -2.6, 95% confidence interval [CI]: -3.5 to -1.7; female: -2.6, 95% CI: -4.8 to -0.5) and never-smokers (mean difference: male -1.8, 95% CI: -3 to -0.6; female: -1.4, 95% CI: -2.4 to -0.4). Similarly, the BF of current smokers was lower compared with that of ex-smokers (mean difference: male: -4.3, 95% CI: -7.5 to -1.2; female: -3.4, 95% CI: -6.4 to -0.4) and never-smokers (mean difference: male: -3.3, 95% CI: -6.3 to -0.4; female: -2.1, 95% CI: -4 to -0.2). FFM did not differ between groups. Finally, current smokers had a significantly smaller waist circumference compared with ex-smokers only (mean difference: male: -6.2, 95% CI: -10.4 to -1.9; female: -7.8, 95% CI: -13.5 to -2.1). Following adjustments for age, disease duration, and HAQ score, smoking remained a significant predictor for BMI (P < 0.001), BF (P < 0.05), and waist circumference (P < 0.05). Pack-years were inversely correlated with BF (r = -0.46; P < 0.001), and heavy smokers exhibited a significantly lower FFM (P < 0.05) compared with all other participants. CONCLUSION: Within the limitations of a cross-sectional study, it appears that cigarette smoking associates with reduced BMI and BF in patients with RA and heavy smoking associates with lower muscle mass. Smoking cessation appears to associate with increased BMI, BF, and waist circumference in these patients. These results should be confirmed in prospective studies. Given the numerous adverse effects of smoking on general health and RA, patients should be actively advised against it. However, smoking cessation regimes in RA may need to include more general lifestyle counselling, particularly about weight control.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://arthritis-research.com/content/10/3/R59en
dc.titleCigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational studyen
dc.typeArticleen
dc.identifier.journalArthritis Research & Therapyen

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