Blockade of tumour necrosis factor-{alpha} in rheumatoid arthritis: effects on components of rheumatoid cachexia

2.50
Hdl Handle:
http://hdl.handle.net/2436/35393
Title:
Blockade of tumour necrosis factor-{alpha} in rheumatoid arthritis: effects on components of rheumatoid cachexia
Authors:
Metsios, Giorgos S.; Stavropoulos-Kalinoglou, Antonios; Douglas, Karen M. J.; Koutedakis, Yiannis; Nevill, Alan M.; Panoulas, Vasileios F.; Kita, Marina D.; Kitas, George D.
Abstract:
Objectives. Rheumatoid arthritis (RA) is accompanied by increased resting energy expenditure (REE) and decreased fat-free mass (FFM). This is referred to as rheumatoid cachexia and is attributed to high levels of tumour necrosis factor-{alpha} (TNF-{alpha}). This study aimed to investigate the effects of anti-TNF-{alpha} therapy on REE, body composition, physical activity and protein intake in RA patients. Methods. Twenty RA patients [50% female; age: (mean ± S.D.) 61.1 ± 6.8 yrs; body mass index (BMI): 28.3 ± 3.7 kg/m2] and 12 age–sex–BMI-matched healthy controls were assessed. REE (indirect calorimetry), body composition (bioelectrical impedance), the International Physical Activity Questionnaire (IPAQ), diet, Health Assessment Questionnaire (HAQ), disease activity [disease activity score 28 (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein] and serum TNF-{alpha} were measured before (Baseline) as well as 2 weeks (Time-1) and 12 weeks (Time-2) after initiation of anti-TNF-{alpha} treatment. Controls were only assessed at Baseline. Results. RA patients had significantly higher REE than controls at Baseline (1799.4 ± 292.0 vs 1502.9 ± 114.5 kcal/day, P = 0.002). Within the RA group, REE increased significantly between Time-1 and Time-2 (P = 0.001) but not between Baseline and Time-2. Sustained significant increases were observed in IPAQ (P = 0.001) and protein intake (P = 0.001). There were no significant changes in FFM or body fat. ESR (P = 0.002), DAS28 (P < 0.001), HAQ (P < 0.001) and TNF-{alpha} (P = 0.024) improved significantly. Physical activity (P = 0.001) and protein intake (P = 0.024) were significant between-subject factors for the elevation of REE. Conclusions. After 12 weeks of anti-TNF-{alpha} therapy, there were significant improvements in disease activity and physical function, as well as physical activity and protein intake, but no significant changes in REE or FFM. There is a need for longer-term studies in this field.
Citation:
Rheumatology, 46(12): 1824-1827
Publisher:
Oxford University Press (Oxford Journals)
Journal:
Rheumatology
Issue Date:
2007
URI:
http://hdl.handle.net/2436/35393
DOI:
10.1093/rheumatology/kem291
Additional Links:
http://rheumatology.oxfordjournals.org/cgi/content/abstract/46/12/1824
Type:
Article
Language:
en
ISSN:
14620324; 14602172
Appears in Collections:
Sport, Exercise and Health Research Group; Exercise and Health; Learning and Teaching in Sport, Exercise and Performance

Full metadata record

DC FieldValue Language
dc.contributor.authorMetsios, Giorgos S.-
dc.contributor.authorStavropoulos-Kalinoglou, Antonios-
dc.contributor.authorDouglas, Karen M. J.-
dc.contributor.authorKoutedakis, Yiannis-
dc.contributor.authorNevill, Alan M.-
dc.contributor.authorPanoulas, Vasileios F.-
dc.contributor.authorKita, Marina D.-
dc.contributor.authorKitas, George D.-
dc.date.accessioned2008-08-13T13:34:33Z-
dc.date.available2008-08-13T13:34:33Z-
dc.date.issued2007-
dc.identifier.citationRheumatology, 46(12): 1824-1827en
dc.identifier.issn14620324-
dc.identifier.issn14602172-
dc.identifier.doi10.1093/rheumatology/kem291-
dc.identifier.urihttp://hdl.handle.net/2436/35393-
dc.description.abstractObjectives. Rheumatoid arthritis (RA) is accompanied by increased resting energy expenditure (REE) and decreased fat-free mass (FFM). This is referred to as rheumatoid cachexia and is attributed to high levels of tumour necrosis factor-{alpha} (TNF-{alpha}). This study aimed to investigate the effects of anti-TNF-{alpha} therapy on REE, body composition, physical activity and protein intake in RA patients. Methods. Twenty RA patients [50% female; age: (mean ± S.D.) 61.1 ± 6.8 yrs; body mass index (BMI): 28.3 ± 3.7 kg/m2] and 12 age–sex–BMI-matched healthy controls were assessed. REE (indirect calorimetry), body composition (bioelectrical impedance), the International Physical Activity Questionnaire (IPAQ), diet, Health Assessment Questionnaire (HAQ), disease activity [disease activity score 28 (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein] and serum TNF-{alpha} were measured before (Baseline) as well as 2 weeks (Time-1) and 12 weeks (Time-2) after initiation of anti-TNF-{alpha} treatment. Controls were only assessed at Baseline. Results. RA patients had significantly higher REE than controls at Baseline (1799.4 ± 292.0 vs 1502.9 ± 114.5 kcal/day, P = 0.002). Within the RA group, REE increased significantly between Time-1 and Time-2 (P = 0.001) but not between Baseline and Time-2. Sustained significant increases were observed in IPAQ (P = 0.001) and protein intake (P = 0.001). There were no significant changes in FFM or body fat. ESR (P = 0.002), DAS28 (P < 0.001), HAQ (P < 0.001) and TNF-{alpha} (P = 0.024) improved significantly. Physical activity (P = 0.001) and protein intake (P = 0.024) were significant between-subject factors for the elevation of REE. Conclusions. After 12 weeks of anti-TNF-{alpha} therapy, there were significant improvements in disease activity and physical function, as well as physical activity and protein intake, but no significant changes in REE or FFM. There is a need for longer-term studies in this field.en
dc.language.isoenen
dc.publisherOxford University Press (Oxford Journals)en
dc.relation.urlhttp://rheumatology.oxfordjournals.org/cgi/content/abstract/46/12/1824en
dc.subjectAnti-TNF-{alpha}en
dc.subjectResting energy expenditureen
dc.subjectMetabolismen
dc.subjectRheumatoid Cachexiaen
dc.subjectRheumatoid Arthritisen
dc.subjectAdipose Tissueen
dc.subjectCytokinesen
dc.subjectInflammationen
dc.subjectMuscleen
dc.subjectBiological therapyen
dc.subjectArthritis, Rheumatoid-
dc.titleBlockade of tumour necrosis factor-{alpha} in rheumatoid arthritis: effects on components of rheumatoid cachexiaen
dc.typeArticleen
dc.identifier.journalRheumatologyen
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