Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis

2.50
Hdl Handle:
http://hdl.handle.net/2436/35375
Title:
Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis
Authors:
Stavropoulos-Kalinoglou, Antonios; Metsios, Giorgos S.; Panoulas, Vasileios F.; Douglas, Karen M. J.; Nevill, Alan M.; Jamurtas, Athanasios Z.; Kita, Marina D.; Koutedakis, Yiannis; Kitas, George D.
Abstract:
OBJECTIVES: To assess the associations of body mass index (BMI) with modifiable cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA). METHODS: BMI, disease activity, selected CVD risk factors and CVD medication were assessed in 378 (276 females) RA patients. Patients exceeding accepted thresholds in >/=3 CVD risk factors were classified as having the metabolic syndrome (MetS). RESULTS: BMI independently associated with hypertension (OR=1.28 (95% CI=1.22-1.34); p=0.001), HDL (OR=1.10 (1.06-1.15); p=0.025), insulin resistance (OR= 1.13 (1.08-1.18); p=0.000) and the MetS (OR=1.15 (1.08-1.21); p=0.000). In multivariable analyses, BMI had the strongest associations with CVD risk factors (F1-354=8.663, p=0.000), and was followed by lipid-lowering treatment (F1-354=7.651, p=0.000), age (F1-354=7.541, p=0.000), antihypertensive treatment (F1-354=4.997, p=0.000) and gender (F1-354=4.707, p=0.000). Prevalence of hypertension (p=0.004), insulin resistance (p=0.005) and the MetS (p=0.000) was significantly different between normal, overweight and obese RA patients, and BMI differed significantly according to the number of risk factors present (p=0.000). CONCLUSIONS: Increasing BMI associates with increased CVD risk independently of many confounders. RA-specific BMI cut-off points better identify RA patients at increased CVD risk. Weight-loss regimes should be developed and applied in order to reduce CVD in RA patients.
Citation:
Annals of the Rheumatic Diseases, 3 August 2008: online
Publisher:
BMJ Publishing
Journal:
Annals of the Rheumatic Diseases
Issue Date:
2008
URI:
http://hdl.handle.net/2436/35375
DOI:
10.1136/ard.2008.095596
PubMed ID:
18677010
Type:
Article
Language:
en
ISSN:
1468-2060
Appears in Collections:
Sport, Exercise and Health Research Group; Exercise and Health; Learning and Teaching in Sport, Exercise and Performance

Full metadata record

DC FieldValue Language
dc.contributor.authorStavropoulos-Kalinoglou, Antonios-
dc.contributor.authorMetsios, Giorgos S.-
dc.contributor.authorPanoulas, Vasileios F.-
dc.contributor.authorDouglas, Karen M. J.-
dc.contributor.authorNevill, Alan M.-
dc.contributor.authorJamurtas, Athanasios Z.-
dc.contributor.authorKita, Marina D.-
dc.contributor.authorKoutedakis, Yiannis-
dc.contributor.authorKitas, George D.-
dc.date.accessioned2008-08-13T13:08:01Z-
dc.date.available2008-08-13T13:08:01Z-
dc.date.issued2008-
dc.identifier.citationAnnals of the Rheumatic Diseases, 3 August 2008: onlineen
dc.identifier.issn1468-2060-
dc.identifier.pmid18677010-
dc.identifier.doi10.1136/ard.2008.095596-
dc.identifier.urihttp://hdl.handle.net/2436/35375-
dc.description.abstractOBJECTIVES: To assess the associations of body mass index (BMI) with modifiable cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA). METHODS: BMI, disease activity, selected CVD risk factors and CVD medication were assessed in 378 (276 females) RA patients. Patients exceeding accepted thresholds in >/=3 CVD risk factors were classified as having the metabolic syndrome (MetS). RESULTS: BMI independently associated with hypertension (OR=1.28 (95% CI=1.22-1.34); p=0.001), HDL (OR=1.10 (1.06-1.15); p=0.025), insulin resistance (OR= 1.13 (1.08-1.18); p=0.000) and the MetS (OR=1.15 (1.08-1.21); p=0.000). In multivariable analyses, BMI had the strongest associations with CVD risk factors (F1-354=8.663, p=0.000), and was followed by lipid-lowering treatment (F1-354=7.651, p=0.000), age (F1-354=7.541, p=0.000), antihypertensive treatment (F1-354=4.997, p=0.000) and gender (F1-354=4.707, p=0.000). Prevalence of hypertension (p=0.004), insulin resistance (p=0.005) and the MetS (p=0.000) was significantly different between normal, overweight and obese RA patients, and BMI differed significantly according to the number of risk factors present (p=0.000). CONCLUSIONS: Increasing BMI associates with increased CVD risk independently of many confounders. RA-specific BMI cut-off points better identify RA patients at increased CVD risk. Weight-loss regimes should be developed and applied in order to reduce CVD in RA patients.en
dc.languageENG-
dc.language.isoenen
dc.publisherBMJ Publishingen
dc.subjectBody Mass Indexen
dc.subjectObesityen
dc.subjectCardiovascular Diseaseen
dc.subjectMetabolic Syndromeen
dc.subjectWeight lossen
dc.titleAssociations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritisen
dc.typeArticleen
dc.identifier.journalAnnals of the Rheumatic Diseasesen

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