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The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells
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| Title: | The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells |
| Authors: | Holton, Marylouisa
Yang, Di
Wang, Weiguang
Mohamed, Tamer M. A.
Neyses, Ludwig
Armesilla, Angel Luis |
| Citation: | FEBS Letters, 581(21): 4115-4119 |
| Publisher: | Elsevier |
| Journal: | FEBS Letters |
| Issue Date: | 2007 |
| URI: | http://hdl.handle.net/2436/33739 |
| DOI: | 10.1016/j.febslet.2007.07.054 |
| PubMed ID: | 17689535 |
| Additional Links: | http://www.febsletters.org/article/S0014-5793(07)00831-9/abstract |
| Abstract: | Plasma membrane calcium/calmodulin-dependent ATPases (PMCAs) are high affinity calcium pumps that extrude calcium from the cell. Emerging evidence suggests a novel role for PMCAs as regulators of calcium/calmodulin-dependent signal transduction pathways via interaction with specific partner proteins. In this work, we demonstrate that endogenous human PMCA2 and -4 both interact with the signal transduction phosphatase, calcineurin, whereas, no interaction was detected with PMCA1. The strongest interaction was observed between PMCA2 and calcineurin. The domain of PMCA2 involved in the interaction is equivalent to that reported for PMCA4b. PMCA2-calcineurin interaction results in inhibition of the calcineurin/nuclear factor of activated T-cells signalling pathway. |
| Type: | Article |
| Language: | en |
| Keywords: | PMCA
Calcineurin
Interaction
MCF-7
Signalling
NFAT |
| MeSH: | Breast Neoplasms
Calcineurin
Calmodulin
Cell Line, Tumor
Cell Membrane
Humans
Isoenzymes
NFATC Transcription Factors
Neoplasm Proteins
Plasma Membrane Calcium-Transporting ATPases
Protein Binding
Protein Structure, Tertiary
Signal Transduction |
| ISSN: | 0014-5793 |
| Appears in Collections: | Molecular Pharmacology Research Group
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| Related articles on PubMed |  | The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.Buch MH, Pickard A, Rodriguez A, Gillies S, Maass AH, Emerson M, Cartwright EJ, Williams JC, Oceandy D, Redondo JM, Neyses L, Armesilla AL 2005 Aug 19 |
| | | Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.Baggott RR, Mohamed TM, Oceandy D, Holton M, Blanc MC, Roux-Soro SC, Brown S, Brown JE, Cartwright EJ, Wang W, Neyses L, Armesilla AL 2012 Dec |
| | | Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1).Armesilla AL, Williams JC, Buch MH, Pickard A, Emerson M, Cartwright EJ, Oceandy D, Vos MD, Gillies S, Clark GJ, Neyses L 2004 Jul 23 |
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